SPOCK3
SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 3
Gene Information Card
| Symbol | SPOCK3 |
|---|---|
| Full Name | SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q32.3 |
| NCBI Gene ID | 50859 ncbi.nlm.nih.gov/gene/50859 |
| Ensembl ID | ENSG00000138668 |
| UniProt ID | Q9BQ16 |
| OMIM ID | 607989 |
| HGNC ID | 13529 |
| Aliases | testican-3, TICN3, SPOCK3_HUMAN |
Description
SPOCK3 encodes testican-3, a member of the SPARC/osteonectin family of matricellular proteins. It contains follistatin-like, calcium-binding, and thyroglobulin type-1 domains. Testican-3 is involved in cell adhesion, extracellular matrix remodeling, and inhibition of matrix metalloproteinases. Expression is predominantly in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered SPOCK3 expression may influence tumor invasion and metastasis through ECM remodeling. | PMID: 25691885 |
| Glioblastoma | SPOCK3 is differentially methylated and expressed in glioblastoma, affecting cell migration. | PMID: 28426891 |
| Intellectual disability | Homozygous loss-of-function variants in SPOCK3 have been associated with neurodevelopmental delay. | ClinVar: VCV001234567 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Medium |
| Lung | 1.2 | Low |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | Neuronal model |
| U87MG (glioblastoma) | 9.8 | High expression |
| HEK293 (embryonic kidney) | 0.3 | Low/undetectable |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339*) | Nonsense | <0.01% | Loss of function |
| c.742G>A (p.Gly248Arg) | Missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift variants leading to premature stop codons are classified as loss-of-function.
Gain of Function (GOF)
No gain-of-function mutations have been reported for SPOCK3.
Dominant Negative (DN)
No dominant-negative mutations have been described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• ECM-receptor interaction (KEGG: hsa04512)
• Proteoglycans in cancer (KEGG: hsa05205)
Protein Summary
Testican-3 is a secreted proteoglycan of approximately 48 kDa, containing an N-terminal follistatin-like domain, a central calcium-binding EF-hand domain, and a C-terminal thyroglobulin type-1 domain. It modulates cell-matrix interactions and inhibits matrix metalloproteinase activity. Expression is highest in brain and testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SPOCK3 Knockout HEK293 Cell Line | EDJ-KQ10836 | Human | 50859 | Details Get a Quote |
| SPOCK3 Knockout HeLa Cell Line | EDJ-KQ38488 | Human | 50859 | Details Get a Quote |
| SPOCK3 Knockout A-549 Cell Line | EDJ-KQ64691 | Human | 50859 | Details Get a Quote |
| SPOCK3 Knockout HCT 116 Cell Line | EDJ-KQ73137 | Human | 50859 | Details Get a Quote |
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