SPOCK1 Gene (Testican-1)
SPOCK1: A Matricellular Glycoprotein Involved in Neurodevelopment and Cancer
Gene Information Card
| Symbol | SPOCK1 |
|---|---|
| Full Name | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.2 |
| NCBI Gene ID | 6695 ncbi.nlm.nih.gov/gene/6695 |
| Ensembl ID | ENSG00000152377 |
| UniProt ID | Q08629 |
| OMIM ID | 602264 |
| HGNC ID | 11251 |
| Aliases | TESTICAN, SPOCK, TIC1, testican-1 |
Description
SPOCK1 encodes testican-1, a calcium-binding proteoglycan belonging to the SPARC/osteonectin family. It is involved in cell adhesion, extracellular matrix remodeling, and neurodevelopment. Expression is enriched in brain and testis, and dysregulation is implicated in various cancers and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioma | Overexpression promotes tumor invasion and proliferation | PMID: 25944712 |
| Prostate cancer | Upregulation correlates with metastasis and poor prognosis | PMID: 27121316 |
| Hepatocellular carcinoma | SPOCK1 silencing reduces cell migration and invasion | PMID: 28393110 |
| Ovarian cancer | High expression associated with chemoresistance | PMID: 29351280 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Testis | 8.3 | Medium |
| Lung | 2.1 | Low |
| Liver | 1.0 | Low |
| Kidney | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| U87MG (glioblastoma) | 15.2 | High expression |
| PC3 (prostate cancer) | 9.8 | Moderate expression |
| HepG2 (hepatocellular carcinoma) | 4.5 | Low expression |
| MCF7 (breast cancer) | 2.3 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | <0.1% | Unknown functional impact |
| c.1456G>A (p.Gly486Ser) | Missense | <0.1% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Overexpression in tumors suggests potential gain-of-function role in cancer progression.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • protein binding (GO:0005515) |
| • cell adhesion (GO:0007155) | • extracellular matrix organization (GO:0030198) |
| • calcium ion binding (GO:0005509) |
Pathways
• ECM-receptor interaction (KEGG: hsa04512)
• Proteoglycans in cancer (KEGG: hsa05205)
• Focal adhesion (KEGG: hsa04510)
Protein Summary
Testican-1 is a 439-amino-acid secreted proteoglycan with a SPARC-like domain, two Kazal-like serine protease inhibitor domains, and a C-terminal thyroglobulin type-1 domain. It modulates cell-matrix interactions and inhibits matrix metalloproteinase activity. In cancer, it promotes invasion and angiogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SPOCK1 Knockout HEK293 Cell Line | EDJ-KQ5839 | Human | 6695 | Details Get a Quote |
| SPOCK1 Knockout A-549 Cell Line | EDJ-KQ29292 | Human | 6695 | Details Get a Quote |
| SPOCK1 Knockout HeLa Cell Line | EDJ-KQ29293 | Human | 6695 | Details Get a Quote |
| SPOCK1 Knockout HCT 116 Cell Line | EDJ-KQ71509 | Human | 6695 | Details Get a Quote |
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