SPINK14 Gene: Function, Expression, and Clinical Significance | Biomedical Database

SPINK14 (Serine Peptidase Inhibitor Kazal Type 14) is a protein-coding gene located on chromosome 5q32. It belongs to the Kazal-type serine protease inhibitor family, which typically function as protease inhibitors. SPINK14 is predicted to encode a secreted protein containing a Kazal-like domain. Its exact physiological role is not fully characterized, but it may be involved in protease regulation in specific tissues. Expression data from the Human Protein Atlas indicate low to moderate expression in certain tissues, with limited disease associations reported.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No specific pathways curated for SPINK14 in major databases.

SPINK14 is a predicted secreted protein with a Kazal-type serine protease inhibitor domain. It is likely involved in regulating proteolytic activity in extracellular environments. The protein is encoded by a gene on chromosome 5q32 and shows low expression in a few tissues, suggesting a specialized or limited role. Its function remains largely uncharacterized, and no disease associations have been established.