SPATA25 (Spermatogenesis Associated 25)
A testis-specific gene implicated in male fertility and spermatogenesis
Gene Information Card
| Symbol | SPATA25 |
|---|---|
| Full Name | Spermatogenesis Associated 25 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | 221468 ncbi.nlm.nih.gov/gene/221468 |
| Ensembl ID | ENSG00000196411 |
| UniProt ID | Q8N6M3 |
| OMIM ID | 614170 |
| HGNC ID | 28372 |
| Aliases | C20orf75, dJ1042K10.5 |
Description
SPATA25 (Spermatogenesis Associated 25) is a protein-coding gene located on chromosome 20q13.33. It is predominantly expressed in the testis and is thought to play a role in spermatogenesis. The encoded protein is localized to the cytoplasm and may be involved in sperm development and male fertility. Limited functional studies exist, and its precise molecular mechanism remains under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility | Potential role in spermatogenesis; reduced expression may impair sperm production | Limited; inferred from testis-specific expression and animal models |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Other tissues | <1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Testicular germ cells | 12.5 | Primary cells |
| Sertoli cells | 0.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown; predicted to affect protein start |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • spermatogenesis | • male gamete generation |
| • cytoplasm |
Pathways
• Spermatogenesis
Protein Summary
The SPATA25 protein (UniProt Q8N6M3) is a 147-amino acid protein with no characterized domains. It is predicted to be cytoplasmic and testis-specific. Its exact biochemical function is unknown, but it is presumed to be involved in the later stages of sperm development.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SPATA25 Knockout HEK293 Cell Line | EDJ-KQ9176 | Human | 128497 | Details Get a Quote |
| SPATA25 Knockout HeLa Cell Line | EDJ-KQ35720 | Human | 128497 | Details Get a Quote |
| SPATA25 Knockout A-549 Cell Line | EDJ-KQ66728 | Human | 128497 | Details Get a Quote |
| SPATA25 Knockout HCT 116 Cell Line | EDJ-KQ75139 | Human | 128497 | Details Get a Quote |
