SPANXN3: Sperm Protein Associated with the Nucleus on the X Chromosome N3
A testis-specific cancer/testis antigen with potential roles in spermatogenesis and tumor immunity
Gene Information Card
| Symbol | SPANXN3 |
|---|---|
| Full Name | SPANX family member N3 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq27.3 |
| NCBI Gene ID | 100132288 ncbi.nlm.nih.gov/gene/100132288 |
| Ensembl ID | ENSG00000283041 |
| UniProt ID | A6NGU5 |
| OMIM ID | Not available |
| HGNC ID | 37208 |
| Aliases | SPANX-N3, SPANX family member N3 |
Description
SPANXN3 is a member of the SPANX (sperm protein associated with the nucleus on the X chromosome) family, located on chromosome Xq27.3. This gene is predominantly expressed in testis and is classified as a cancer/testis antigen (CTA). CTAs are normally restricted to male germ cells but can be aberrantly expressed in various cancers, making them attractive targets for immunotherapy. SPANXN3 is part of a multi-gene family that arose through duplication events on the X chromosome. Its exact function is not fully characterized, but it is believed to play a role in spermatogenesis, particularly in sperm nuclear structure and chromatin remodeling. Due to its testis-restricted expression and potential upregulation in tumors, SPANXN3 is being investigated as a biomarker and immunotherapeutic target.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Aberrant expression in tumors; potential as a cancer/testis antigen triggering immune response | Inferred from family members; direct evidence limited |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | High (based on RNA-seq data from GTEx, though specific nTPM not provided) |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No specific cell line data available | Not available | No data |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not available | Not available | No data |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • nucleus | • sperm chromatin |
| • DNA binding |
Pathways
• Spermatogenesis
• Cancer/testis antigen pathway
Protein Summary
The SPANXN3 protein is a small, basic protein localized to the nucleus of sperm cells. It contains a conserved SPANX domain and is thought to interact with DNA or chromatin. Its expression is tightly regulated during spermatogenesis, and it may be involved in the compaction of sperm chromatin. In cancer, its aberrant expression could lead to immune recognition, as it is not normally present in adult somatic tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SPANXN3 Knockout HEK293 Cell Line | EDJ-KQ9491 | Human | 139067 | Details Get a Quote |
| SPANXN3 Knockout HeLa Cell Line | EDJ-KQ58403 | Human | 139067 | Details Get a Quote |
| SPANXN3 Knockout A-549 Cell Line | EDJ-KQ66892 | Human | 139067 | Details Get a Quote |
| SPANXN3 Knockout HCT 116 Cell Line | EDJ-KQ75294 | Human | 139067 | Details Get a Quote |
