SOX15
SRY-box transcription factor 15
Gene Information Card
| Symbol | SOX15 |
|---|---|
| Full Name | SRY-box transcription factor 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 6665 ncbi.nlm.nih.gov/gene/6665 |
| Ensembl ID | ENSG00000129194 |
| UniProt ID | O60248 |
| OMIM ID | 601297 |
| HGNC ID | 11196 |
| Aliases | SOX-15, SOX20, SOX-20 |
Description
SOX15 (SRY-box transcription factor 15) is a member of the SOX (SRY-related HMG-box) family of transcription factors. It contains a high-mobility group (HMG) box DNA-binding domain and is involved in the regulation of embryonic development, cell fate determination, and spermatogenesis. SOX15 is expressed in multiple tissues, with highest levels in testis, and has been implicated in various cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Testicular germ cell tumors | SOX15 expression is altered in testicular germ cell tumors, potentially affecting differentiation pathways. | PubMed: 23434518 |
| Colorectal cancer | SOX15 acts as a tumor suppressor; promoter hypermethylation leads to silencing in colorectal cancer. | PubMed: 25652263 |
| Gastric cancer | Reduced SOX15 expression correlates with poor prognosis; may regulate cell proliferation. | PubMed: 27381352 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 38.2 | High |
| Thyroid | 12.5 | Medium |
| Prostate | 8.9 | Medium |
| Lung | 6.1 | Low |
| Colon | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NTERA-2 (embryonal carcinoma) | 15.7 | High expression; used in differentiation studies |
| HCT116 (colorectal carcinoma) | 2.1 | Low expression due to promoter methylation |
| A549 (lung carcinoma) | 4.5 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.1% | Likely loss of start codon; effect unknown |
| c.202C>T (p.Arg68Trp) | missense | <0.1% | Reported in COSMIC; functional impact unclear |
| Promoter hypermethylation | epigenetic | Common in colorectal cancer | Silences SOX15 expression |
Mutation functional classification
Loss of Function (LOF)
Promoter hypermethylation and missense mutations in the HMG domain may reduce DNA binding and transcriptional activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• SOX-mediated regulation of stem cell pluripotency
• Embryonic development (HMG-box transcription factors)
Protein Summary
SOX15 is a 233-amino acid protein (UniProt O60248) with a single HMG box domain (residues 30-98) that binds DNA in a sequence-specific manner. It localizes to the nucleus and regulates target genes involved in cell cycle, differentiation, and development. Post-translational modifications include phosphorylation, which may modulate its activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SOX15 Knockout HEK293 Cell Line | EDJ-KQ50645 | Human | 6665 | Details Get a Quote |
| SOX15 Knockout HeLa Cell Line | EDJ-KQ54541 | Human | 6665 | Details Get a Quote |
| SOX15 Knockout A-549 Cell Line | EDJ-KQ63025 | Human | 6665 | Details Get a Quote |
| SOX15 Knockout HCT 116 Cell Line | EDJ-KQ71501 | Human | 6665 | Details Get a Quote |
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