SOCS7: Suppressor of Cytokine Signaling 7
A key regulator of cytokine signaling and insulin receptor trafficking
Gene Information Card
| Symbol | SOCS7 |
|---|---|
| Full Name | Suppressor of Cytokine Signaling 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 30837 ncbi.nlm.nih.gov/gene/30837 |
| Ensembl ID | ENSG00000120885 |
| UniProt ID | O14512 |
| OMIM ID | 608788 |
| HGNC ID | 16842 |
| Aliases | SOCS-7, NAP4, NCKAP4, ADAM2 |
Description
SOCS7 (Suppressor of Cytokine Signaling 7) is a member of the SOCS family of proteins that function as negative regulators of cytokine signaling via the JAK/STAT pathway. It contains an SH2 domain and a SOCS box domain. SOCS7 is involved in insulin receptor internalization and trafficking, and plays a role in cell growth, differentiation, and immune response. Mutations and altered expression of SOCS7 have been implicated in cancer, diabetes, and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered SOCS7 expression may disrupt cytokine signaling and promote tumorigenesis | COSMIC; PMID: 21573173 |
| Prostate cancer | SOCS7 downregulation associated with poor prognosis and increased STAT3 activation | COSMIC; PMID: 22664980 |
| Type 2 diabetes | SOCS7 impairs insulin receptor trafficking and signaling | OMIM 608788; PMID: 17202158 |
| Developmental delay / intellectual disability | Homozygous loss-of-function mutations in SOCS7 reported | ClinVar; PMID: 25439727 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 10.2 | Medium |
| Kidney | 8.9 | Medium |
| Liver | 6.3 | Low |
| Heart | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | Embryonic kidney cells; high expression |
| HeLa | 11.7 | Cervical cancer cells; moderate expression |
| MCF7 | 9.4 | Breast cancer cells; moderate expression |
| HepG2 | 7.8 | Liver cancer cells; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1246C>T (p.Arg416Ter) | Nonsense | Rare | Loss of function; truncation of SOCS box |
| c.832G>A (p.Gly278Arg) | Missense | Rare | Unknown; located in SH2 domain |
| c.1687_1688del (p.Leu563GlufsTer5) | Frameshift | Rare | Loss of function; premature termination |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations that truncate the SOCS box or SH2 domain impair negative regulation of cytokine signaling.
Gain of Function (GOF)
No gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• JAK-STAT signaling pathway (KEGG: hsa04630)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Insulin signaling pathway (KEGG: hsa04910)
Protein Summary
SOCS7 is a 582-amino acid protein containing an N-terminal region, a central SH2 domain that binds phosphorylated tyrosine residues, and a C-terminal SOCS box that mediates interactions with the ubiquitin-proteasome system. It functions as a negative regulator of cytokine signaling by inhibiting JAK kinase activity and targeting signaling proteins for degradation. SOCS7 also regulates insulin receptor endocytosis and trafficking, influencing glucose homeostasis. Its expression is tissue-specific, with highest levels in brain and testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SOCS7 Knockout HEK293 Cell Line | EDJ-KQ530 | Human | 30837 | Details Get a Quote |
| SOCS7 Knockout A-549 Cell Line | EDJ-KQ18882 | Human | 30837 | Details Get a Quote |
| SOCS7 Knockout HCT 116 Cell Line | EDJ-KQ18883 | Human | 30837 | Details Get a Quote |
| SOCS7 Knockout HeLa Cell Line | EDJ-KQ18884 | Human | 30837 | Details Get a Quote |
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