SOCS2: Suppressor of Cytokine Signaling 2
A key negative regulator of JAK/STAT signaling, implicated in growth, development, and cancer.
Gene Information Card
| Symbol | SOCS2 |
|---|---|
| Full Name | Suppressor of Cytokine Signaling 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q22 |
| NCBI Gene ID | 8835 ncbi.nlm.nih.gov/gene/8835 |
| Ensembl ID | ENSG00000120833 |
| UniProt ID | O14508 |
| OMIM ID | 605117 |
| HGNC ID | 16882 |
| Aliases | CIS2, SOCS-2, SSI-2, STATI2 |
Description
SOCS2 (Suppressor of Cytokine Signaling 2) encodes a member of the SOCS (suppressor of cytokine signaling) family, which are negative regulators of cytokine receptor signaling via the JAK/STAT pathway. SOCS2 inhibits signaling by binding to phosphorylated tyrosine residues on cytokine receptors and targeting associated JAK kinases for proteasomal degradation. It plays a critical role in growth hormone (GH) and insulin-like growth factor 1 (IGF1) signaling, and its dysregulation is linked to growth abnormalities and various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Growth hormone insensitivity with immune dysregulation | Loss-of-function mutations in SOCS2 lead to enhanced GH signaling, resulting in growth abnormalities and immune defects. | PMID: 15630409 |
| Breast cancer | SOCS2 overexpression is associated with poor prognosis and may promote tumor growth via altered JAK/STAT signaling. | PMID: 17634559 |
| Prostate cancer | SOCS2 hypermethylation and reduced expression correlate with disease progression and metastasis. | PMID: 23361059 |
| Colorectal cancer | SOCS2 downregulation is linked to increased STAT3 activation and tumor progression. | PMID: 22179823 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Kidney | 8.7 | Medium |
| Heart | 5.2 | Low |
| Brain | 3.1 | Low |
| Skeletal Muscle | 2.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.6 | High expression |
| MCF7 | 9.8 | Moderate expression |
| HepG2 | 7.4 | Moderate expression |
| A549 | 4.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.458C>T (p.Pro153Leu) | Missense | <0.1% | Loss of function; reduced ability to inhibit STAT5 signaling |
| c.1A>G (p.Met1Val) | Start loss | <0.1% | Loss of function; likely no protein expression |
| c.622_623insA (p.Thr208Asnfs*2) | Frameshift | <0.1% | Loss of function; premature truncation |
Mutation functional classification
Loss of Function (LOF)
Most reported SOCS2 mutations are loss-of-function, impairing its ability to downregulate JAK/STAT signaling, leading to enhanced cytokine responses.
Gain of Function (GOF)
Gain-of-function mutations in SOCS2 are rare and not well characterized; overexpression in some cancers may mimic gain-of-function effects.
Dominant Negative (DN)
No dominant-negative mutations have been reported for SOCS2.
View complete mutation data：
Gene Ontology (GO)
| • negative regulation of JAK-STAT cascade | • protein ubiquitination |
| • cytokine-mediated signaling pathway | • growth hormone receptor signaling pathway |
| • intracellular signal transduction |
Pathways
• JAK-STAT signaling pathway (KEGG: hsa04630)
• Growth hormone signaling (Reactome: R-HSA-982772)
• Cytokine signaling in immune system (Reactome: R-HSA-1280215)
Protein Summary
The SOCS2 protein (UniProt O14508) is 198 amino acids long and contains an N-terminal SH2 domain that binds phosphorylated tyrosine residues on cytokine receptors, and a C-terminal SOCS box that recruits the ubiquitin-transferase machinery. It functions as a key negative feedback regulator of JAK/STAT signaling, particularly downstream of growth hormone and prolactin receptors. SOCS2 is localized in the cytoplasm and nucleus, and its expression is induced by cytokine stimulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SOCS2 Knockout HEK293 Cell Line | EDJ-KQ526 | Human | 8835 | Details Get a Quote |
| SOCS2 Knockout A-549 Cell Line | EDJ-KQ18866 | Human | 8835 | Details Get a Quote |
| SOCS2 Knockout HCT 116 Cell Line | EDJ-KQ18867 | Human | 8835 | Details Get a Quote |
| SOCS2 Knockout HeLa Cell Line | EDJ-KQ18868 | Human | 8835 | Details Get a Quote |
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