SNX25: Sorting Nexin 25
A member of the sorting nexin family involved in intracellular trafficking and signaling
Gene Information Card
| Symbol | SNX25 |
|---|---|
| Full Name | Sorting Nexin 25 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q35.1 |
| NCBI Gene ID | 115761 ncbi.nlm.nih.gov/gene/115761 |
| Ensembl ID | ENSG00000138614 |
| UniProt ID | Q9H3E2 |
| OMIM ID | 615138 |
| HGNC ID | 30586 |
| Aliases | FLJ12735, MGC138396 |
Description
SNX25 encodes a member of the sorting nexin family, characterized by a phox (PX) domain that binds phosphoinositides and mediates protein-protein interactions. The protein is involved in intracellular trafficking, endocytosis, and signal transduction. It may play a role in regulating cell surface receptor recycling and degradation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect receptor trafficking and signaling pathways | COSMIC; literature |
| No specific monogenic disease reported | Not established | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Medium |
| Lung | 3.8 | Low |
| Liver | 2.1 | Low |
| Kidney | 4.5 | Low |
| Testis | 6.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.0 | Moderate expression |
| HeLa | 3.5 | Moderate expression |
| A549 | 2.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | <0.01% | Unknown functional impact |
| c.567C>T (p.Pro189Leu) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • intracellular protein transport (GO:0006886) | • endocytosis (GO:0006897) |
| • phosphatidylinositol binding (GO:0035091) | • protein binding (GO:0005515) |
Pathways
• Endocytosis (Reactome: R-HSA-199991)
• Membrane Trafficking (Reactome: R-HSA-199991)
Protein Summary
The SNX25 protein contains a PX domain that binds phosphatidylinositol 3-phosphate, targeting it to endosomal membranes. It is involved in sorting and trafficking of membrane proteins, potentially regulating receptor signaling. Expression is detected in multiple tissues, with highest levels in testis and brain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SNX25 Knockout HEK293 Cell Line | EDJ-KQ9114 | Human | 83891 | Details Get a Quote |
| SNX25 Knockout A-549 Cell Line | EDJ-KQ36824 | Human | 83891 | Details Get a Quote |
| SNX25 Knockout HCT 116 Cell Line | EDJ-KQ36826 | Human | 83891 | Details Get a Quote |
| SNX25 Knockout HeLa Cell Line | EDJ-KQ36827 | Human | 83891 | Details Get a Quote |
