SNX24: Sorting Nexin 24
A member of the sorting nexin family involved in intracellular trafficking and endosomal sorting
Gene Information Card
| Symbol | SNX24 |
|---|---|
| Full Name | Sorting Nexin 24 |
| Gene Type | Protein-coding |
| Chromosomal Location | 5q23.2 |
| NCBI Gene ID | 28966 ncbi.nlm.nih.gov/gene/28966 |
| Ensembl ID | ENSG00000164327 |
| UniProt ID | Q9Y3X0 |
| OMIM ID | 615906 |
| HGNC ID | 30574 |
| Aliases | MGC11102, SBBI31 |
Description
SNX24 (sorting nexin 24) encodes a member of the sorting nexin family, characterized by a phox (PX) domain that binds phosphoinositides. The protein is involved in intracellular trafficking, endosomal sorting, and may play a role in regulating cell signaling. SNX24 is widely expressed and has been implicated in cellular processes including membrane remodeling and protein transport.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 10.2 | Low |
| Lung | 8.5 | Low |
| Liver | 6.1 | Low |
| Kidney | 7.3 | Low |
| Testis | 12.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Low expression |
| HeLa | 7.5 | Low expression |
| K562 | 6.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • intracellular protein transport (GO:0006886) | • protein transport (GO:0015031) |
| • phosphatidylinositol binding (GO:0035091) | • endosome (GO:0005768) |
| • Golgi apparatus (GO:0005794) |
Pathways
• Endosomal sorting complex required for transport (ESCRT) - related
• Phosphoinositide-mediated signaling
Protein Summary
SNX24 is a 162-amino acid protein containing a PX domain that binds phosphatidylinositol 3-phosphate (PI3P), targeting it to endosomal membranes. It is involved in endosomal trafficking and may regulate protein sorting and signaling. The protein is ubiquitously expressed at low levels.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SNX24 Knockout HEK293 Cell Line | EDJ-KQ8944 | Human | 28966 | Details Get a Quote |
| SNX24 Knockout HeLa Cell Line | EDJ-KQ34072 | Human | 28966 | Details Get a Quote |
| SNX24 Knockout A-549 Cell Line | EDJ-KQ35302 | Human | 28966 | Details Get a Quote |
| SNX24 Knockout HCT 116 Cell Line | EDJ-KQ35303 | Human | 28966 | Details Get a Quote |
