SNX15: Sorting Nexin 15
A member of the sorting nexin family involved in endosomal trafficking and cellular signaling.
Gene Information Card
| Symbol | SNX15 |
|---|---|
| Full Name | Sorting Nexin 15 |
| Gene Type | Protein-coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 29907 ncbi.nlm.nih.gov/gene/29907 |
| Ensembl ID | ENSG00000110367 |
| UniProt ID | Q9Y5W7 |
| OMIM ID | 605164 |
| HGNC ID | 14977 |
| Aliases | MGC8721, SNX15A, SNX15B |
Description
SNX15 encodes a member of the sorting nexin family, which are involved in intracellular trafficking and endosomal sorting. The protein contains a Phox (PX) domain that binds phosphoinositides and mediates membrane association. SNX15 is implicated in endosome-to-Golgi transport and may play a role in cell signaling and receptor recycling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may disrupt endosomal trafficking and signaling pathways, contributing to tumorigenesis. | COSMIC; limited direct evidence |
| Neurodegenerative disorders | Potential involvement in endosomal dysfunction, though specific mechanisms are not well established. | NCBI Gene; inferred from family function |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.1 | Cervical cancer cell line |
| HEK293 | 9.5 | Embryonic kidney cell line |
| K562 | 7.8 | Leukemia cell line |
| A549 | 6.4 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437C>T (p.Pro146Leu) | Missense | <0.1% | Unknown; predicted benign by in silico tools |
| c.682G>A (p.Gly228Arg) | Missense | <0.1% | Unknown; predicted possibly damaging |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • endosome (GO:0005768) | • phosphatidylinositol binding (GO:0035091) |
| • intracellular protein transport (GO:0006886) | • protein transport (GO:0015031) |
| • phosphatidylinositol-4 (GO:0005546) |
Pathways
• Endosomal trafficking (Reactome: R-HSA-199991)
• Membrane trafficking (Reactome: R-HSA-199991)
Protein Summary
SNX15 is a 324-amino acid protein containing a PX domain that targets it to endosomal membranes. It is involved in endosome-to-Golgi transport and may regulate the trafficking of receptors and signaling molecules. Expression is highest in testis, with lower levels in brain and other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SNX15 Knockout HEK293 Cell Line | EDJ-KQ9076 | Human | 29907 | Details Get a Quote |
| SNX15 Knockout A-549 Cell Line | EDJ-KQ35557 | Human | 29907 | Details Get a Quote |
| SNX15 Knockout HCT 116 Cell Line | EDJ-KQ35558 | Human | 29907 | Details Get a Quote |
| SNX15 Knockout HeLa Cell Line | EDJ-KQ35559 | Human | 29907 | Details Get a Quote |
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