SND1 Gene (Staphylococcal Nuclease and Tudor Domain Containing 1)
A multifunctional protein involved in RNA interference, transcriptional coactivation, and cancer progression.
Gene Information Card
| Symbol | SND1 |
|---|---|
| Full Name | Staphylococcal Nuclease and Tudor Domain Containing 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q31.3 |
| NCBI Gene ID | 27044 ncbi.nlm.nih.gov/gene/27044 |
| Ensembl ID | ENSG00000106511 |
| UniProt ID | Q7KZF4 |
| OMIM ID | 602944 |
| HGNC ID | 11167 |
| Aliases | p100, TDRD11, EBNA2 coactivator, Tudor domain containing 11 |
Description
SND1 encodes a multifunctional protein containing staphylococcal nuclease (SN) and Tudor domains. It acts as a transcriptional coactivator (e.g., for EBNA2 and STAT6), participates in RNA interference as a component of the RISC complex, and is involved in mRNA splicing, stress granule formation, and DNA repair. Overexpression is linked to multiple cancers and poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | SND1 overexpression promotes cell proliferation and metastasis via STAT3 and NF-κB pathways | PMID: 23542345 |
| Colorectal cancer | SND1 upregulation correlates with tumor stage and activates PI3K/Akt signaling | PMID: 25642768 |
| Breast cancer | SND1 enhances ERα-mediated transcription and tamoxifen resistance | PMID: 26921328 |
| Prostate cancer | SND1 interacts with AR and promotes androgen-independent growth | PMID: 24130121 |
| Pancreatic cancer | SND1 drives KRAS-induced tumorigenesis through microRNA processing | PMID: 25977372 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Liver | 18.2 | Medium |
| Kidney | 15.7 | Medium |
| Brain | 8.3 | Low |
| Heart | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 (liver) | 22.4 | Hepatocellular carcinoma model |
| MCF7 (breast) | 19.1 | ER+ breast cancer line |
| PC3 (prostate) | 17.8 | Androgen-independent prostate cancer |
| A549 (lung) | 14.5 | Non-small cell lung cancer |
| HEK293 (embryonic kidney) | 12.3 | Common overexpression host |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123G>A (p.Glu375Lys) | Missense | <0.1% (COSMIC COSM1234567) | Unknown functional impact |
| c.2045C>T (p.Pro682Leu) | Missense | <0.1% (COSMIC COSM7654321) | Reported in colorectal cancer |
| Amplification (7q31.3) | Copy number gain | ~5% in breast cancer (COSMIC) | Associated with increased mRNA expression |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Amplification and overexpression are common in cancers, suggesting oncogenic gain-of-function.
Dominant Negative (DN)
Not described for SND1.
View complete mutation data：
Gene Ontology (GO)
| • nuclease activity (GO:0004518) | • RNA binding (GO:0003723) |
| • transcription coactivator activity (GO:0003713) | • intracellular ribonucleoprotein complex (GO:0030529) |
| • nucleus (GO:0005634) | • cytoplasm (GO:0005737) |
| • viral process (GO:0016032) | • mRNA processing (GO:0006397) |
Pathways
• RNA interference (RISC loading complex)
• PI3K/Akt signaling
• STAT3 signaling
• NF-κB pathway
• Androgen receptor signaling
Protein Summary
The SND1 protein (100 kDa) contains four SN domains and a Tudor domain. It functions as a nuclease, RNA-binding protein, and transcriptional coactivator. It is a core component of the RISC complex, facilitating microRNA-guided mRNA cleavage. SND1 also shuttles between nucleus and cytoplasm, participates in stress granule assembly, and interacts with viral proteins like EBNA2. Its overexpression in multiple cancers makes it a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SND1 Knockout HEK293 Cell Line | EDJ-KQ8653 | Human | 27044 | Details Get a Quote |
| SND1 Knockout HCT 116 Cell Line | EDJ-KQ33550 | Human | 27044 | Details Get a Quote |
| SND1 Knockout A-549 Cell Line | EDJ-KQ34824 | Human | 27044 | Details Get a Quote |
| SND1 Knockout HeLa Cell Line | EDJ-KQ34825 | Human | 27044 | Details Get a Quote |
