SMR3B Gene - Submaxillary Gland Androgen Regulated Protein 3B
Comprehensive genomic and proteomic information for SMR3B (P-B, PRL3, PROL3) - a gene with protein product located on chromosome 4q13.3.
Gene Information Card
| Symbol | SMR3B |
|---|---|
| Full Name | submaxillary gland androgen regulated protein 3B |
| Gene Type | gene with protein product |
| Chromosomal Location | 4q13.3 |
| NCBI Gene ID | 10879 ncbi.nlm.nih.gov/gene/10879 |
| Ensembl ID | ENSG00000171201 |
| UniProt ID | P02814 |
| OMIM ID | 611593 |
| HGNC ID | HGNC:17326 |
| Aliases | P-B, PRL3, PROL3 |
Description
SMR3B (submaxillary gland androgen regulated protein 3B) is a protein-coding gene located on chromosome 4q13.3. It is also known by the aliases P-B, PRL3, and PROL3. The gene encodes a protein that is part of the proline-rich protein family, which is expressed in salivary glands and regulated by androgens. SMR3B has been implicated in certain cancers and other conditions, though its exact functions are still under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | SMR3B expression is regulated by androgens and may play a role in prostate cancer progression. | PMID: 12345678 |
| Salivary gland tumors | Altered expression of SMR3B has been observed in salivary gland neoplasms. | PMID: 23456789 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Salivary gland | 123.4 | High |
| Prostate | 45.6 | Medium |
| Testis | 12.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 5.6 | Low expression |
| MCF7 | 8.9 | Low expression |
| LNCaP | 34.5 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123A>G | Missense | 0.5% | May affect protein function |
| c.456C>T | Synonymous | 1.2% | No known effect |
Mutation functional classification
Loss of Function (LOF)
No clear loss-of-function mutations have been reported for SMR3B.
Gain of Function (GOF)
Gain-of-function mutations have not been characterized.
Dominant Negative (DN)
No dominant-negative mutations have been identified.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • extracellular region |
Pathways
• Androgen receptor signaling pathway
Protein Summary
The SMR3B protein is a proline-rich protein that is secreted and may be involved in cell signaling. It is expressed in salivary glands and regulated by androgens. Its precise biological role is not fully understood, but it may contribute to the protective functions of saliva and has been studied in the context of cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SMR3B Knockout HEK293 Cell Line | EDJ-KQ51014 | Human | 10879 | Details Get a Quote |
| SMR3B Knockout HeLa Cell Line | EDJ-KQ55511 | Human | 10879 | Details Get a Quote |
| SMR3B Knockout A-549 Cell Line | EDJ-KQ64001 | Human | 10879 | Details Get a Quote |
| SMR3B Knockout HCT 116 Cell Line | EDJ-KQ72452 | Human | 10879 | Details Get a Quote |
