SMIM24: Small Integral Membrane Protein 24
A gene encoding a small transmembrane protein with limited functional characterization.
Gene Information Card
| Symbol | SMIM24 |
|---|---|
| Full Name | Small Integral Membrane Protein 24 |
| Gene Type | Protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 100506142 ncbi.nlm.nih.gov/gene/100506142 |
| Ensembl ID | ENSG00000205730 |
| UniProt ID | A6NKD9 |
| OMIM ID | - |
| HGNC ID | 44165 |
| Aliases | C19orf82, MGC16384 |
Description
SMIM24 (Small Integral Membrane Protein 24) is a protein-coding gene located on chromosome 19q13.33. It encodes a small transmembrane protein of unknown function. The gene is conserved in mammals and is expressed in various tissues. Limited functional data are available, and no disease associations have been firmly established.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No confirmed disease associations | - | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Thyroid | 3.8 | Low |
| Prostate | 3.1 | Low |
| Adrenal gland | 2.9 | Low |
| Lung | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.1 | Moderate expression |
| K562 | 2.3 | Low expression |
| HeLa | 1.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.55C>T | Synonymous | <0.01% | Likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane (GO:0016021) |
Protein Summary
SMIM24 is a small integral membrane protein with a single transmembrane domain. Its biological function remains largely unknown, and no protein structure has been experimentally determined.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SMIM24 Knockout HEK293 Cell Line | EDJ-KQ2520 | Human | 284422 | Details Get a Quote |
| SMIM24 Knockout A-549 Cell Line | EDJ-KQ23133 | Human | 284422 | Details Get a Quote |
| SMIM24 Knockout HeLa Cell Line | EDJ-KQ23134 | Human | 284422 | Details Get a Quote |
| SMIM24 Knockout HCT 116 Cell Line | EDJ-KQ76312 | Human | 284422 | Details Get a Quote |
