SLIT1: Slit Guidance Ligand 1
A key axon guidance molecule in neural development and cancer
Gene Information Card
| Symbol | SLIT1 |
|---|---|
| Full Name | Slit Guidance Ligand 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q24.1 |
| NCBI Gene ID | 6585 ncbi.nlm.nih.gov/gene/6585 |
| Ensembl ID | ENSG00000187122 |
| UniProt ID | O75093 |
| OMIM ID | 603742 |
| HGNC ID | 11085 |
| Aliases | SLIT1, slit homolog 1, slit-1 |
Description
SLIT1 encodes a secreted glycoprotein that functions as a ligand for Roundabout (ROBO) receptors. It plays a critical role in axon guidance and neuronal migration during development by repelling growing axons. SLIT1 is also implicated in cell adhesion, angiogenesis, and tumor suppression. The protein contains leucine-rich repeats (LRRs) and epidermal growth factor (EGF)-like domains.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Altered SLIT1 expression may disrupt neuronal connectivity and synaptic plasticity. | NCBI Gene, OMIM |
| Colorectal Cancer | SLIT1 promoter hypermethylation leads to silencing, contributing to tumor progression. | COSMIC, ClinVar |
| Breast Cancer | Reduced SLIT1 expression associated with metastasis and poor prognosis. | NCBI Gene, COSMIC |
| Prostate Cancer | SLIT1 downregulation via methylation promotes invasion. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Spinal Cord | 8.3 | Medium |
| Lung | 1.2 | Low |
| Breast | 0.5 | Not detected |
| Colon | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.0 | Neuronal model |
| U-87 MG (glioblastoma) | 9.8 | Glial origin |
| MCF7 (breast cancer) | 0.2 | Low expression |
| HCT116 (colorectal cancer) | 0.1 | Silenced by methylation |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function |
| c.567G>A (p.Trp189*) | Nonsense | <0.1% | Loss of function |
| c.890_891insA | Frameshift | <0.1% | Loss of function |
| Promoter hypermethylation | Epigenetic | Common in cancer | Transcriptional silencing |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations truncate the protein, disrupting ligand-receptor interaction and axon guidance.
Gain of Function (GOF)
No gain-of-function mutations reported in SLIT1.
Dominant Negative (DN)
No dominant-negative mutations reported in SLIT1.
View complete mutation data：
Gene Ontology (GO)
| • axon guidance (GO:0007411) | • cell adhesion (GO:0007155) |
| • protein binding (GO:0005515) | • extracellular region (GO:0005576) |
| • cell differentiation (GO:0030154) | • signal transduction (GO:0007165) |
Pathways
• Axon guidance (KEGG: hsa04360)
• Slit/Robo signaling (Reactome: R-HSA-9013408)
• Netrin-mediated signaling (Reactome: R-HSA-373752)
Protein Summary
SLIT1 is a secreted 1530-amino acid glycoprotein with multiple LRR and EGF-like domains. It binds ROBO1/2 receptors to mediate chemorepulsion in neuronal development. The protein is also involved in cell migration and angiogenesis. In cancer, SLIT1 is frequently silenced by promoter methylation, leading to loss of tumor-suppressive function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLIT1 Knockout HEK293 Cell Line | EDJ-KQ5801 | Human | 6585 | Details Get a Quote |
| SLIT1 Knockout HeLa Cell Line | EDJ-KQ54521 | Human | 6585 | Details Get a Quote |
| SLIT1 Knockout A-549 Cell Line | EDJ-KQ63006 | Human | 6585 | Details Get a Quote |
| SLIT1 Knockout HCT 116 Cell Line | EDJ-KQ71478 | Human | 6585 | Details Get a Quote |
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