SLFN5 Gene - Schlafen Family Member 5
A comprehensive resource on SLFN5, including genomic data, expression, mutations, and disease associations.
Gene Information Card
| Symbol | SLFN5 |
|---|---|
| Full Name | Schlafen family member 5 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 162394 ncbi.nlm.nih.gov/gene/162394 |
| Ensembl ID | ENSG00000187608 |
| UniProt ID | Q08AF3 |
| OMIM ID | 614538 |
| HGNC ID | 26287 |
| Aliases | SLFN5, Schlafen5, FLJ30656 |
Description
SLFN5 (Schlafen family member 5) is a protein-coding gene belonging to the Schlafen family, which is involved in cell growth regulation, immune response, and antiviral activity. The gene is located on chromosome 17q12 and encodes a protein that may play a role in inhibiting cell proliferation and modulating interferon signaling. SLFN5 has been implicated in various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | SLFN5 expression is altered in multiple cancers, potentially affecting cell cycle and immune evasion. | COSMIC, NCBI |
| Inflammatory bowel disease | SLFN5 polymorphisms may influence susceptibility to Crohn's disease. | OMIM, NCBI |
| Viral infections | SLFN5 may restrict viral replication through interferon-related pathways. | UniProt, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Kidney | 6.1 | Low |
| Liver | 4.2 | Low |
| Brain | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 15.0 | High expression |
| HEK293 (embryonic kidney) | 9.5 | Moderate expression |
| HepG2 (liver cancer) | 5.0 | Low expression |
| K562 (leukemia) | 3.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1000C>T (p.Arg334Trp) | Missense | <0.1% | Unknown functional impact |
| c.1456G>A (p.Glu486Lys) | Missense | <0.1% | Reported in COSMIC |
| c.789_790insA | Frameshift | <0.1% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.789_790insA) are predicted to cause loss of function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • DNA binding | • ATP binding |
| • regulation of cell cycle | • negative regulation of cell proliferation |
| • response to interferon-gamma |
Pathways
• Interferon signaling
• Cell cycle regulation
Protein Summary
The SLFN5 protein is a member of the Schlafen family, characterized by an AAA domain and a nuclear localization signal. It is involved in DNA binding and ATP hydrolysis, and it negatively regulates cell proliferation. SLFN5 is induced by interferons and may contribute to antiviral responses and tumor suppression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLFN5 Knockout HEK293 Cell Line | EDJ-KQ12149 | Human | 162394 | Details Get a Quote |
| SLFN5 Knockout A-549 Cell Line | EDJ-KQ40844 | Human | 162394 | Details Get a Quote |
| SLFN5 Knockout HCT 116 Cell Line | EDJ-KQ40845 | Human | 162394 | Details Get a Quote |
| SLFN5 Knockout HeLa Cell Line | EDJ-KQ40846 | Human | 162394 | Details Get a Quote |
