SLCO5A1
Solute Carrier Organic Anion Transporter Family Member 5A1
Gene Information Card
| Symbol | SLCO5A1 |
|---|---|
| Full Name | Solute Carrier Organic Anion Transporter Family Member 5A1 |
| Gene Type | protein-coding |
| Chromosomal Location | 8q13.3 |
| NCBI Gene ID | 81796 ncbi.nlm.nih.gov/gene/81796 |
| Ensembl ID | ENSG00000137575 |
| UniProt ID | Q9H2Y9 |
| OMIM ID | 612435 |
| HGNC ID | 10955 |
| Aliases | OATP5A1, OATP-J, SLC21A15 |
Description
SLCO5A1 (Solute Carrier Organic Anion Transporter Family Member 5A1) is a protein-coding gene that belongs to the organic anion transporting polypeptide (OATP) family. The encoded protein mediates the sodium-independent transport of organic anions, including bile acids, steroid conjugates, and various drugs. It is expressed in multiple tissues and may play a role in drug disposition and endocrine regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered expression of SLCO5A1 may influence androgen transport and signaling, potentially affecting tumor progression. | PMID: 23542377 |
| Colorectal cancer | SLCO5A1 expression is upregulated in colorectal cancer tissues and may contribute to chemoresistance by transporting anticancer drugs. | PMID: 25910214 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 2.1 | Low |
| Kidney | 1.5 | Low |
| Prostate | 4.3 | Medium |
| Colon | 3.8 | Medium |
| Testis | 2.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 1.8 | Hepatocellular carcinoma cell line |
| LNCaP | 5.2 | Prostate cancer cell line |
| Caco-2 | 3.5 | Colorectal adenocarcinoma cell line |
| HEK293 | 0.9 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100G>A (p.Gly34Arg) | Missense | <0.01% | Unknown functional effect |
| c.1456C>T (p.Arg486Trp) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • organic anion transmembrane transporter activity (GO:0008514) | • bile acid transmembrane transporter activity (GO:0015125) |
| • symporter activity (GO:0015293) | • integral component of membrane (GO:0016021) |
| • transmembrane transport (GO:0055085) |
Pathways
• Transport of organic anions (Reactome: R-HSA-879518)
• Bile acid and bile salt metabolism (Reactome: R-HSA-194068)
Protein Summary
The SLCO5A1 protein (UniProt Q9H2Y9) is a 724-amino acid multi-pass membrane protein with 12 transmembrane domains. It functions as a sodium-independent organic anion transporter, facilitating the uptake of substrates such as bile acids, steroid conjugates, and xenobiotics. The protein is localized to the plasma membrane and is expressed in various tissues including liver, kidney, prostate, and colon.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLCO5A1 Knockout HEK293 Cell Line | EDJ-KQ9749 | Human | 81796 | Details Get a Quote |
| SLCO5A1 Knockout HeLa Cell Line | EDJ-KQ57414 | Human | 81796 | Details Get a Quote |
| SLCO5A1 Knockout A-549 Cell Line | EDJ-KQ65920 | Human | 81796 | Details Get a Quote |
| SLCO5A1 Knockout HCT 116 Cell Line | EDJ-KQ74347 | Human | 81796 | Details Get a Quote |
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