SLC6A16
Solute Carrier Family 6 Member 16
Gene Information Card
| Symbol | SLC6A16 |
|---|---|
| Full Name | Solute Carrier Family 6 Member 16 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 23244 ncbi.nlm.nih.gov/gene/23244 |
| Ensembl ID | ENSG00000104879 |
| UniProt ID | Q9GZN6 |
| OMIM ID | 607972 |
| HGNC ID | 11019 |
| Aliases | NTT5, FLJ20488 |
Description
SLC6A16 (Solute Carrier Family 6 Member 16) is a protein-coding gene located on chromosome 19q13.33. It encodes a member of the sodium- and chloride-dependent neurotransmitter transporter family, though its specific substrate and physiological function remain incompletely characterized. The gene is expressed in various tissues and may play a role in amino acid or neurotransmitter transport.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations confirmed | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 2.1 | Low |
| Kidney | 1.8 | Low |
| Liver | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.5 | Low expression |
| HeLa | 0.3 | Low expression |
| K562 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • neurotransmitter:sodium symporter activity (GO:0005328) | • symporter activity (GO:0015293) |
| • integral component of plasma membrane (GO:0005887) | • neurotransmitter transport (GO:0006836) |
Pathways
• Neurotransmitter uptake and metabolism
Protein Summary
The SLC6A16 protein (UniProt Q9GZN6) is a predicted multi-pass membrane protein with 12 transmembrane domains, characteristic of the SLC6 family. It is thought to function as a sodium- and chloride-dependent transporter, but its endogenous substrate has not been identified. Expression data suggest it may be involved in testicular or neuronal transport processes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC6A16 Knockout HEK293 Cell Line | EDJ-KQ8945 | Human | 28968 | Details Get a Quote |
| SLC6A16 Knockout A-549 Cell Line | EDJ-KQ35305 | Human | 28968 | Details Get a Quote |
| SLC6A16 Knockout HCT 116 Cell Line | EDJ-KQ35306 | Human | 28968 | Details Get a Quote |
| SLC6A16 Knockout HeLa Cell Line | EDJ-KQ56079 | Human | 28968 | Details Get a Quote |
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