SLC43A3
Solute Carrier Family 43 Member 3
Gene Information Card
| Symbol | SLC43A3 |
|---|---|
| Full Name | Solute Carrier Family 43 Member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q11 |
| NCBI Gene ID | 29015 ncbi.nlm.nih.gov/gene/29015 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | Q8NBI5 |
| OMIM ID | 612458 |
| HGNC ID | 10946 |
| Aliases | EEV, LAT3, POV1, PRO0989 |
Description
SLC43A3 encodes a member of the solute carrier family 43, a sodium-independent, system L-like amino acid transporter. The protein mediates the transport of large neutral amino acids across the plasma membrane and is involved in cellular amino acid homeostasis. It is also known as LAT3 (L-type amino acid transporter 3).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Overexpression of SLC43A3 may promote amino acid uptake and tumor growth | PMID: 15616553 |
| Hepatocellular carcinoma | Upregulation associated with poor prognosis and altered metabolism | PMID: 29187742 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 4.2 | Medium |
| Kidney | 3.8 | Medium |
| Prostate | 2.1 | Low |
| Testis | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 5.1 | Hepatocellular carcinoma cell line |
| LNCaP | 3.4 | Prostate cancer cell line |
| HEK293 | 2.0 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional effect |
| c.457G>A (p.Val153Met) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in SLC43A3.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in SLC43A3.
Dominant Negative (DN)
No dominant-negative mutations reported in SLC43A3.
View complete mutation data：
Gene Ontology (GO)
| • amino acid transport (GO:0006865) | • amino acid transmembrane transporter activity (GO:0015171) |
| • integral component of membrane (GO:0016021) | • integral component of plasma membrane (GO:0005887) |
Pathways
• Amino acid transport across the plasma membrane (Reactome: R-HSA-352230)
• SLC-mediated transmembrane transport (Reactome: R-HSA-425407)
Protein Summary
SLC43A3 is a 559-amino acid transmembrane protein with 12 putative transmembrane domains. It functions as a sodium-independent transporter for large neutral amino acids such as leucine, isoleucine, valine, phenylalanine, and tryptophan. The protein is localized to the plasma membrane and is expressed in various tissues, with highest levels in liver and kidney.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC43A3 Knockout HEK293 Cell Line | EDJ-KQ3679 | Human | 29015 | Details Get a Quote |
| SLC43A3 Knockout HCT 116 Cell Line | EDJ-KQ25666 | Human | 29015 | Details Get a Quote |
| SLC43A3 Knockout HeLa Cell Line | EDJ-KQ25667 | Human | 29015 | Details Get a Quote |
| SLC43A3 Knockout A-549 Cell Line | EDJ-KQ64572 | Human | 29015 | Details Get a Quote |
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