SLC39A3: Solute Carrier Family 39 Member 3
Zinc transporter ZIP3 involved in cellular zinc homeostasis and linked to cancer and immune function
Gene Information Card
| Symbol | SLC39A3 |
|---|---|
| Full Name | Solute Carrier Family 39 Member 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 29985 ncbi.nlm.nih.gov/gene/29985 |
| Ensembl ID | ENSG00000141873 |
| UniProt ID | Q9BRY0 |
| OMIM ID | 612168 |
| HGNC ID | 17126 |
| Aliases | ZIP3, ZIP-3 |
Description
SLC39A3 (Solute Carrier Family 39 Member 3) encodes a member of the ZIP (Zrt- and Irt-like protein) family of metal ion transporters. The protein, ZIP3, functions as a zinc influx transporter, facilitating the uptake of zinc from the extracellular space into the cytoplasm. It plays a critical role in maintaining cellular zinc homeostasis, which is essential for numerous biological processes including cell growth, differentiation, and immune function. SLC39A3 is expressed in various tissues and is implicated in cancer progression and inflammatory responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered zinc transport may affect cell proliferation and apoptosis; ZIP3 downregulation observed in malignant prostate tissue | PMID: 16959974 |
| Breast cancer | ZIP3 expression changes influence zinc accumulation and tumor growth | PMID: 17690111 |
| Inflammatory bowel disease | Zinc dysregulation via ZIP3 may contribute to intestinal inflammation | PMID: 23376952 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 12.5 | Medium |
| Breast | 8.3 | Medium |
| Small intestine | 15.1 | High |
| Kidney | 9.7 | Medium |
| Liver | 6.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 14.2 | Moderate expression |
| MCF-7 (breast cancer) | 10.5 | Moderate expression |
| HEK 293 (embryonic kidney) | 8.9 | Moderate expression |
| Caco-2 (colorectal) | 16.8 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | Unknown functional impact |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • zinc ion transmembrane transporter activity (GO:0005385) | • zinc ion transmembrane transport (GO:0070834) |
| • cytoplasm (GO:0005737) | • integral component of membrane (GO:0016021) |
| • metal ion transmembrane transporter activity (GO:0046873) |
Pathways
• Zinc homeostasis (Reactome: R-HSA-435354)
• Metal ion SLC transporters (Reactome: R-HSA-425393)
Protein Summary
ZIP3 is a transmembrane protein with eight predicted transmembrane domains, localized primarily to the plasma membrane and intracellular vesicles. It mediates zinc uptake into cells, contributing to zinc-dependent signaling and enzyme function. The protein is expressed in multiple tissues, with highest levels in the small intestine and prostate. Alterations in ZIP3 expression are associated with cancer and inflammatory conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC39A3 Knockout HEK293 Cell Line | EDJ-KQ9119 | Human | 29985 | Details Get a Quote |
| SLC39A3 Knockout A-549 Cell Line | EDJ-KQ35634 | Human | 29985 | Details Get a Quote |
| SLC39A3 Knockout HCT 116 Cell Line | EDJ-KQ35635 | Human | 29985 | Details Get a Quote |
| SLC39A3 Knockout HeLa Cell Line | EDJ-KQ35636 | Human | 29985 | Details Get a Quote |
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