SLC39A10: Zinc Transporter ZIP10
Solute Carrier Family 39 Member 10 – Zinc Homeostasis and Disease Association
Gene Information Card
| Symbol | SLC39A10 |
|---|---|
| Full Name | Solute Carrier Family 39 Member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q33.1 |
| NCBI Gene ID | 57181 ncbi.nlm.nih.gov/gene/57181 |
| Ensembl ID | ENSG00000115956 |
| UniProt ID | Q9BRX2 |
| OMIM ID | 608730 |
| HGNC ID | 20387 |
| Aliases | ZIP10, LZT-Hs2, BCG-1 |
Description
SLC39A10 encodes ZIP10, a member of the Zrt/Irt-like protein (ZIP) family that mediates zinc uptake into cells from the extracellular space. Zinc is an essential trace element required for numerous cellular processes including enzyme function, transcription, and signal transduction. ZIP10 is localized to the plasma membrane and plays a role in zinc homeostasis, cell proliferation, and immune response. Dysregulation of SLC39A10 has been implicated in cancer progression and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of ZIP10 increases intracellular zinc, promoting cell proliferation and migration | PMID: 25329317 |
| Prostate cancer | Altered zinc transport via ZIP10 contributes to malignant transformation | PMID: 21804537 |
| B-cell acute lymphoblastic leukemia | ZIP10 expression correlates with poor prognosis and drug resistance | PMID: 29127120 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 12.5 nTPM | Medium |
| Prostate | 8.3 nTPM | Low |
| Lung | 6.7 nTPM | Low |
| Liver | 4.1 nTPM | Low |
| Kidney | 3.9 nTPM | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 nTPM | High expression |
| PC3 (prostate cancer) | 9.8 nTPM | Moderate expression |
| A549 (lung cancer) | 7.1 nTPM | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123G>A (p.Gly375Arg) | Missense | <0.01% | Unknown functional effect |
| c.1456C>T (p.Arg486Trp) | Missense | <0.01% | Unknown functional effect |
| c.1789_1791del (p.Phe597del) | In-frame deletion | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • zinc ion transmembrane transporter activity (GO:0005385) | • zinc ion transmembrane transport (GO:0071577) |
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
Pathways
• Zinc homeostasis (Reactome: R-HSA-435354)
• Metal ion SLC transporters (KEGG: hsa04976)
Protein Summary
ZIP10 (UniProt Q9BRX2) is a 10-transmembrane domain protein that functions as a zinc importer. It is expressed on the plasma membrane and facilitates zinc entry into cells, thereby regulating intracellular zinc levels. ZIP10 is involved in cell growth, survival, and immune cell function. Its expression is upregulated in several cancers and is associated with poor prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC39A10 Knockout HEK293 Cell Line | EDJ-KQ15343 | Human | 57181 | Details Get a Quote |
| SLC39A10 Knockout A-549 Cell Line | EDJ-KQ46065 | Human | 57181 | Details Get a Quote |
| SLC39A10 Knockout HCT 116 Cell Line | EDJ-KQ46066 | Human | 57181 | Details Get a Quote |
| SLC39A10 Knockout HeLa Cell Line | EDJ-KQ46067 | Human | 57181 | Details Get a Quote |
