SLC39A1: Zinc Transporter ZIP1
A key regulator of cellular zinc homeostasis with implications in cancer and development
Gene Information Card
| Symbol | SLC39A1 |
|---|---|
| Full Name | Solute Carrier Family 39 Member 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 27173 ncbi.nlm.nih.gov/gene/27173 |
| Ensembl ID | ENSG00000116285 |
| UniProt ID | Q9NY26 |
| OMIM ID | 604731 |
| HGNC ID | 11012 |
| Aliases | ZIP1, ZIRTL |
Description
SLC39A1 (solute carrier family 39 member 1) encodes the zinc transporter ZIP1, which mediates cellular uptake of zinc from the extracellular space. Zinc is an essential trace element required for numerous enzymatic, structural, and regulatory functions. ZIP1 is ubiquitously expressed and plays a critical role in maintaining intracellular zinc homeostasis. Dysregulation of SLC39A1 has been implicated in prostate cancer, where loss of ZIP1 expression leads to zinc accumulation defects and malignant transformation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | Loss of ZIP1 expression reduces intracellular zinc, promoting tumorigenesis via altered citrate metabolism and increased oxidative stress. | PMID: 14612522; NCBI GeneRIF |
| Zinc Deficiency | Impaired ZIP1 function may contribute to systemic zinc deficiency, affecting immune function and growth. | OMIM #604731; UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Kidney | 7.1 | Medium |
| Small Intestine | 6.9 | Medium |
| Brain | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.2 | Cervical cancer cell line |
| HepG2 | 9.5 | Hepatocellular carcinoma |
| PC-3 | 4.8 | Prostate cancer cell line (low expression) |
| MCF7 | 7.3 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown; predicted benign by ClinVar |
| c.215G>A (p.Arg72His) | Missense | <0.01% | Unknown; predicted benign by ClinVar |
Mutation functional classification
Loss of Function (LOF)
Loss of ZIP1 function reduces zinc uptake, linked to prostate cancer progression.
Gain of Function (GOF)
Not reported in SLC39A1.
Dominant Negative (DN)
Not reported in SLC39A1.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005385 - zinc ion transmembrane transporter activity | • GO:0006829 - zinc ion transport |
| • GO:0016021 - integral component of membrane | • GO:0071294 - cellular response to zinc ion |
Pathways
• Zinc homeostasis (Reactome: R-HSA-435354)
• Metal ion SLC transporters (KEGG: hsa04976)
Protein Summary
ZIP1 is a transmembrane protein with eight predicted transmembrane domains, localized to the plasma membrane and intracellular vesicles. It functions as a homodimer to import zinc into the cytosol. The protein contains a histidine-rich motif essential for zinc binding and transport. ZIP1 is regulated at transcriptional and post-translational levels by zinc availability.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC39A13 Knockout HEK293 Cell Line | EDJ-KQ1374 | Human | 91252 | Details Get a Quote |
| SLC39A14 Knockout HEK293 Cell Line | EDJ-KQ2426 | Human | 23516 | Details Get a Quote |
| SLC39A11 Knockout HEK293 Cell Line | EDJ-KQ4798 | Human | 201266 | Details Get a Quote |
| SLC39A1 Knockout HEK293 Cell Line | EDC08027 | Human | 27173 | Details Get a Quote |
| SLC39A12 Knockout HEK293 Cell Line | EDJ-KQ8797 | Human | 221074 | Details Get a Quote |
| SLC39A10 Knockout HEK293 Cell Line | EDJ-KQ15343 | Human | 57181 | Details Get a Quote |
| SLC39A13 Knockout A-549 Cell Line | EDJ-KQ22167 | Human | 91252 | Details Get a Quote |
| SLC39A13 Knockout HCT 116 Cell Line | EDC07723 | Human | 91252 | Details Get a Quote |
| SLC39A13 Knockout HeLa Cell Line | EDJ-KQ22170 | Human | 91252 | Details Get a Quote |
| SLC39A14 Knockout HCT 116 Cell Line | EDJ-KQ22938 | Human | 23516 | Details Get a Quote |
| SLC39A14 Knockout HeLa Cell Line | EDJ-KQ22939 | Human | 23516 | Details Get a Quote |
| SLC39A1 Knockout A-549 Cell Line | EDJ-KQ34930 | Human | 27173 | Details Get a Quote |
| SLC39A1 Knockout HCT 116 Cell Line | EDJ-KQ34931 | Human | 27173 | Details Get a Quote |
| SLC39A10 Knockout A-549 Cell Line | EDJ-KQ46065 | Human | 57181 | Details Get a Quote |
| SLC39A10 Knockout HCT 116 Cell Line | EDJ-KQ46066 | Human | 57181 | Details Get a Quote |
Displaying Records 1 To 15 Of 24 Records
