SLC38A9
Solute Carrier Family 38 Member 9: A Lysosomal Amino Acid Transporter and Nutrient Sensor
Gene Information Card
| Symbol | SLC38A9 |
|---|---|
| Full Name | Solute Carrier Family 38 Member 9 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q11.2 |
| NCBI Gene ID | 153129 ncbi.nlm.nih.gov/gene/153129 |
| Ensembl ID | ENSG00000177054 |
| UniProt ID | Q8IWR0 |
| OMIM ID | 616101 |
| HGNC ID | 26959 |
| Aliases | SNAT9, URLC11, FLJ90709 |
Description
SLC38A9 (Solute Carrier Family 38 Member 9) encodes a lysosomal transmembrane protein that functions as an amino acid transporter, particularly for arginine. It acts as a nutrient sensor within the lysosome, regulating the mTORC1 signaling pathway in response to amino acid availability. The protein interacts with the Ragulator complex to facilitate mTORC1 activation. SLC38A9 is also implicated in cellular growth, metabolism, and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Dysregulation of mTORC1 signaling via altered SLC38A9 expression or function may promote cell growth and proliferation. | COSMIC; literature (e.g., PMID: 25849865) |
| Metabolic disorders | Impaired amino acid sensing and mTORC1 activity linked to insulin resistance and obesity. | OMIM 616101; literature (PMID: 25849865) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Liver | 8.9 | Low |
| Brain | 6.3 | Low |
| Lung | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| HeLa | 12.3 | Medium expression |
| HepG2 | 9.8 | Medium expression |
| A549 | 7.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown; predicted benign |
| c.457G>A (p.Gly153Ser) | Missense | <0.01% | Unknown; predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• mTORC1 signaling (Reactome: R-HSA-165159)
• Amino acid transport across the lysosomal membrane (Reactome: R-HSA-166658)
Protein Summary
SLC38A9 is a 561-amino acid lysosomal membrane protein with 11 transmembrane domains. It belongs to the SLC38 family of sodium-coupled amino acid transporters. The protein localizes to the lysosomal membrane and mediates the efflux of amino acids, particularly arginine, from the lysosome. This efflux is critical for activating the Ragulator-Rag complex and subsequently mTORC1, linking nutrient availability to cell growth. Structural studies reveal a transporter fold with a central substrate-binding site.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC38A9 Knockout HEK293T Cell Line | EDJ-KQ214 | Human | 153129 | Details Get a Quote |
| SLC38A9 Knockout HEK293 Cell Line | EDJ-KQ1142 | Human | 153129 | Details Get a Quote |
| SLC38A9 Knockout HeLa Cell Line | EDJ-KQ18195 | Human | 153129 | Details Get a Quote |
| SLC38A9 Knockout HCT 116 Cell Line | EDJ-KQ18230 | Human | 153129 | Details Get a Quote |
| SLC38A9 Knockout A-549 Cell Line | EDJ-KQ20362 | Human | 153129 | Details Get a Quote |
| Slc38a9 Knockout C2C12 Cell Line | EDJ-KZ474 | Mouse | 268706 | Details Get a Quote |
Displaying Records 1 To 6 Of 6 Records
