SLC38A11: Solute Carrier Family 38 Member 11
A sodium-coupled neutral amino acid transporter with emerging roles in cancer and metabolic regulation.
Gene Information Card
| Symbol | SLC38A11 |
|---|---|
| Full Name | Solute carrier family 38 member 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q24.3 |
| NCBI Gene ID | 151258 ncbi.nlm.nih.gov/gene/151258 |
| Ensembl ID | ENSG00000163002 |
| UniProt ID | Q5JY77 |
| OMIM ID | 616525 |
| HGNC ID | 26979 |
| Aliases | SNAT11, MGC34648 |
Description
SLC38A11 (Solute Carrier Family 38 Member 11) encodes a sodium-coupled neutral amino acid transporter, also known as SNAT11. It belongs to the SLC38 family of transporters that mediate the uptake of small neutral amino acids such as glutamine, alanine, and serine. The protein is predicted to have 11 transmembrane domains and is involved in amino acid homeostasis. Expression is enriched in certain cancer cell lines and tissues, suggesting a role in tumor metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered amino acid transport may support tumor growth and proliferation. | COSMIC; literature (PMID: 30894373) |
| Colorectal cancer | Upregulation of SLC38A11 observed in tumor samples. | NCBI GEO; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.8 | Low |
| Kidney | 0.5 | Low |
| Brain | 0.3 | Low |
| Liver | 0.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.6 | Low expression |
| HeLa | 0.4 | Low expression |
| A549 | 0.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Ile) | Missense | <0.01% | Unknown |
| c.452G>A (p.Arg151Gln) | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Not established; no functional studies confirm LOF.
Gain of Function (GOF)
Not established; no functional studies confirm GOF.
Dominant Negative (DN)
Not established; no evidence.
View complete mutation data：
Gene Ontology (GO)
| • amino acid transmembrane transporter activity (GO:0015171) | • integral component of plasma membrane (GO:0005887) |
| • neutral amino acid transport (GO:0015804) | • transmembrane transport (GO:0055085) |
Pathways
• Amino acid transport across the plasma membrane (Reactome: R-HSA-352230)
Protein Summary
SLC38A11 is a 547-amino acid protein with 11 transmembrane domains, functioning as a sodium-coupled neutral amino acid transporter. It is predicted to localize to the plasma membrane and facilitate the uptake of small neutral amino acids. The protein shares homology with other SLC38 family members but its specific substrate preference and kinetic properties remain incompletely characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC38A11 Knockout HEK293 Cell Line | EDJ-KQ10645 | Human | 151258 | Details Get a Quote |
| SLC38A11 Knockout HeLa Cell Line | EDJ-KQ58684 | Human | 151258 | Details Get a Quote |
| SLC38A11 Knockout A-549 Cell Line | EDJ-KQ67166 | Human | 151258 | Details Get a Quote |
| SLC38A11 Knockout HCT 116 Cell Line | EDJ-KQ75569 | Human | 151258 | Details Get a Quote |
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