SLC37A1: Solute Carrier Family 37 Member 1
A glucose-6-phosphate transporter involved in metabolic and cancer biology
Gene Information Card
| Symbol | SLC37A1 |
|---|---|
| Full Name | Solute Carrier Family 37 Member 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 21q22.3 |
| NCBI Gene ID | 54020 ncbi.nlm.nih.gov/gene/54020 |
| Ensembl ID | ENSG00000160209 |
| UniProt ID | P57057 |
| OMIM ID | 608744 |
| HGNC ID | 10953 |
| Aliases | G6PT3, G3PP, SPX1 |
Description
SLC37A1 encodes a member of the solute carrier family 37, functioning as a glucose-6-phosphate (G6P) transporter. It is involved in gluconeogenesis and the endoplasmic reticulum stress response. The protein is localized to the endoplasmic reticulum membrane and mediates the transport of G6P from the cytoplasm into the ER lumen. SLC37A1 is also implicated in cellular phosphate homeostasis and has been associated with metabolic disorders and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glycogen storage disease type I (non-classical) | Impaired G6P transport leads to disrupted glycogenolysis and gluconeogenesis | OMIM #608744 |
| Hepatocellular carcinoma | Overexpression of SLC37A1 promotes tumor growth via altered glucose metabolism | COSMIC, literature |
| Type 2 diabetes | Variants in SLC37A1 associated with insulin resistance and glucose intolerance | GWAS, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Small intestine | 6.1 | Low |
| Pancreas | 4.7 | Low |
| Adipose tissue | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Liver cancer cell line, high expression |
| HEK293 | 7.8 | Embryonic kidney, moderate expression |
| Caco-2 | 5.4 | Colorectal adenocarcinoma, low expression |
| MCF7 | 2.1 | Breast cancer, very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1040C>T (p.Thr347Met) | Missense | <0.01% | Reduced G6P transport activity |
| c.1256G>A (p.Arg419His) | Missense | <0.01% | Loss of function, associated with metabolic disorder |
| c.1472T>C (p.Ile491Thr) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Missense variants such as p.Arg419His impair G6P transport, leading to metabolic dysregulation.
Gain of Function (GOF)
Not reported in curated databases.
Dominant Negative (DN)
Not reported in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • symporter activity (GO:0015293) | • antiporter activity (GO:0015297) |
| • endoplasmic reticulum (GO:0005783) | • glucose-6-phosphate transport (GO:0015758) |
| • gluconeogenesis (GO:0006094) | • phosphate ion transmembrane transport (GO:0035435) |
Pathways
• Glucoseogenesis (Reactome: R-HSA-70263)
• Glucose-6-phosphate transport (Reactome: R-HSA-189200)
Protein Summary
SLC37A1 is a 429-amino acid multi-pass transmembrane protein localized to the endoplasmic reticulum. It functions as a G6P/phosphate antiporter, critical for gluconeogenesis and glycogenolysis. The protein contains a sugar-phosphate transporter domain and is expressed predominantly in liver and kidney. Structural studies suggest it forms a homodimer. Post-translational modifications include N-glycosylation at Asn-48.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC37A1 Knockout HEK293 Cell Line | EDJ-KQ11377 | Human | 54020 | Details Get a Quote |
| SLC37A1 Knockout A-549 Cell Line | EDJ-KQ39575 | Human | 54020 | Details Get a Quote |
| SLC37A1 Knockout HCT 116 Cell Line | EDJ-KQ39576 | Human | 54020 | Details Get a Quote |
| SLC37A1 Knockout HeLa Cell Line | EDJ-KQ39577 | Human | 54020 | Details Get a Quote |
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