SLC35F5
Solute Carrier Family 35 Member F5
Gene Information Card
| Symbol | SLC35F5 |
|---|---|
| Full Name | Solute Carrier Family 35 Member F5 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 222553 ncbi.nlm.nih.gov/gene/222553 |
| Ensembl ID | ENSG00000162928 |
| UniProt ID | Q8N5K1 |
| OMIM ID | 618769 |
| HGNC ID | 23300 |
| Aliases | FLJ20701, MGC13170 |
Description
SLC35F5 encodes a member of the solute carrier family 35 (SLC35) of nucleotide sugar transporters. The protein is predicted to localize to the Golgi apparatus and endoplasmic reticulum, where it may transport nucleotide sugars required for glycosylation. SLC35F5 is broadly expressed in many tissues and has been implicated in cancer cell proliferation and survival.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Overexpression promotes cell proliferation and invasion; potential oncogenic role | COSMIC; PMID: 31525674 |
| Hepatocellular carcinoma | Upregulation correlates with poor prognosis; may regulate glycosylation pathways | PMID: 32415276 |
| Breast cancer | High expression associated with aggressive subtypes; potential therapeutic target | PMID: 33087226 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Liver | 8.7 | Low |
| Colon | 15.2 | Medium |
| Breast | 10.1 | Medium |
| Lung | 9.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.5 | Moderate expression |
| HeLa | 11.2 | Moderate expression |
| HepG2 | 9.8 | Low expression |
| MCF7 | 13.0 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Ala34Val) | Missense | <0.01% | Unknown; rare variant |
| c.452G>A (p.Arg151His) | Missense | <0.01% | Unknown; rare variant |
| c.788_789insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.788_789insA) are predicted to cause loss of function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Nucleotide sugar transport (Reactome: R-HSA-425407)
• Glycosylation (Reactome: R-HSA-597592)
Protein Summary
SLC35F5 is a 339-amino acid multi-pass membrane protein with 10 predicted transmembrane domains. It belongs to the SLC35 family of nucleotide sugar transporters. The protein is localized to the Golgi and ER membranes and is involved in the transport of nucleotide sugars (e.g., UDP-galactose, GDP-mannose) into the lumen for glycosylation. SLC35F5 is widely expressed and has been linked to cancer progression through altered glycosylation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC35F5 Knockout HEK293 Cell Line | EDJ-KQ9509 | Human | 80255 | Details Get a Quote |
| SLC35F5 Knockout A-549 Cell Line | EDJ-KQ35004 | Human | 80255 | Details Get a Quote |
| SLC35F5 Knockout HCT 116 Cell Line | EDJ-KQ36261 | Human | 80255 | Details Get a Quote |
| SLC35F5 Knockout HeLa Cell Line | EDJ-KQ36262 | Human | 80255 | Details Get a Quote |
