SLC35E4: Solute Carrier Family 35 Member E4
SLC35E4 gene, protein, and disease associations
Gene Information Card
| Symbol | SLC35E4 |
|---|---|
| Full Name | Solute carrier family 35 member E4 |
| Gene Type | Protein coding |
| Chromosomal Location | 22q12.2 |
| NCBI Gene ID | 339665 ncbi.nlm.nih.gov/gene/339665 |
| Ensembl ID | ENSG00000184937 |
| UniProt ID | Q8N7M0 |
| OMIM ID | 618009 |
| HGNC ID | 20872 |
| Aliases | FLJ22662, MGC13170 |
Description
SLC35E4 encodes a member of the solute carrier family 35 (SLC35) of nucleotide-sugar transporters. These proteins are localized to the Golgi apparatus and endoplasmic reticulum and mediate the transport of nucleotide sugars into the lumen for glycosylation reactions. SLC35E4 is predicted to function as a nucleotide-sugar transporter, though its specific substrate and physiological role remain under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No direct evidence from ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Thyroid | 3.8 | Low |
| Adrenal gland | 3.1 | Low |
| Prostate | 2.9 | Low |
| Brain (cerebellum) | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.1 | Low expression |
| HeLa | 3.5 | Low expression |
| K562 | 2.8 | Low expression |
| HepG2 | 2.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • Golgi membrane (GO:0000139) | • nucleotide-sugar transmembrane transporter activity (GO:0005459) |
| • nucleotide-sugar transport (GO:0015780) | • integral component of membrane (GO:0016021) |
Pathways
• Nucleotide-sugar transport (Reactome: R-HSA-425407)
Protein Summary
SLC35E4 is a 339-amino acid multi-pass membrane protein predicted to localize to the Golgi apparatus. It belongs to the SLC35 family of nucleotide-sugar transporters, which are essential for glycosylation. The protein contains conserved domains characteristic of nucleotide-sugar transporters, but its specific substrate and biological function have not been fully characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC35E4 Knockout HEK293 Cell Line | EDJ-KQ15330 | Human | 339665 | Details Get a Quote |
| SLC35E4 Knockout A-549 Cell Line | EDJ-KQ46050 | Human | 339665 | Details Get a Quote |
| SLC35E4 Knockout HCT 116 Cell Line | EDJ-KQ46051 | Human | 339665 | Details Get a Quote |
| SLC35E4 Knockout HeLa Cell Line | EDJ-KQ44830 | Human | 339665 | Details Get a Quote |
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