SLC35E3 Gene - Solute Carrier Family 35 Member E3 | Function, Expression & Disease

SLC35E3 (Solute Carrier Family 35 Member E3) is a protein-coding gene belonging to the SLC35 family of nucleotide sugar transporters. These transporters are involved in the translocation of nucleotide sugars from the cytosol into the Golgi apparatus and endoplasmic reticulum, a critical step for proper glycosylation of proteins and lipids. SLC35E3 is predicted to function as a nucleotide sugar transporter, though its specific substrate and physiological roles are still under investigation. The gene is located on chromosome 12q15 and is expressed in a variety of tissues, with notable levels in the brain, kidney, and testis. Alterations in SLC35E3 expression have been observed in certain cancers, suggesting a potential role in tumor biology.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Nucleotide sugar transport (Reactome: R-HSA-425407)

SLC35E3 encodes a multi-pass transmembrane protein localized to the Golgi apparatus. It is predicted to function as a nucleotide sugar transporter, facilitating the import of nucleotide sugars into the Golgi lumen for use in glycosylation reactions. The protein contains conserved motifs characteristic of the SLC35 family. Its precise substrate specificity remains to be determined, but it is thought to transport UDP-sugars or related molecules. Expression data suggest a role in normal tissue homeostasis and potential involvement in cancer through altered glycosylation.