SLC30A6: Zinc Transporter 6 (ZnT6) – Golgi Apparatus Zinc Homeostasis
Comprehensive genomic, proteomic, and clinical annotation of SLC30A6, a member of the solute carrier family 30 (zinc transporter) involved in zinc efflux from the Golgi apparatus.
Gene Information Card
| Symbol | SLC30A6 |
|---|---|
| Full Name | Solute Carrier Family 30 Member 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 2p22.3 |
| NCBI Gene ID | 55676 ncbi.nlm.nih.gov/gene/55676 |
| Ensembl ID | ENSG00000115956 |
| UniProt ID | Q6NXT4 |
| OMIM ID | 611148 |
| HGNC ID | 19313 |
| Aliases | ZnT6, ZNT6, MGC131895 |
Description
SLC30A6 (Solute Carrier Family 30 Member 6) encodes a member of the zinc transporter (ZnT) family, specifically ZnT6. This protein is localized to the Golgi apparatus and functions as a zinc efflux transporter, moving zinc from the cytoplasm into the Golgi lumen. It plays a critical role in maintaining cellular zinc homeostasis and is involved in zinc-dependent processes such as protein processing and secretion. ZnT6 often forms heterodimers with ZnT5 to mediate efficient zinc transport.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered zinc transport in prostate epithelial cells may contribute to malignant transformation; SLC30A6 expression changes observed in tumor tissues. | PubMed: 21804527 |
| Type 2 diabetes | Zinc homeostasis in pancreatic beta cells is critical for insulin processing; SLC30A6 variants may influence zinc availability. | PubMed: 23468591 |
| Alzheimer's disease | Dysregulation of zinc homeostasis in the brain, including Golgi zinc transport, is implicated in amyloid-beta aggregation. | PubMed: 27383053 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.2 | Medium |
| Pancreas | 7.5 | Medium |
| Prostate | 6.9 | Medium |
| Liver | 5.3 | Low |
| Kidney | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.1 | High expression |
| HeLa | 9.4 | Medium expression |
| HepG2 | 6.2 | Medium expression |
| MCF7 | 5.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% | Unknown; predicted possibly damaging by PolyPhen-2 |
| c.1289G>A (p.Arg430Gln) | Missense | <0.01% | Unknown; predicted benign by SIFT |
| c.1462_1463insA (p.Thr488Asnfs*12) | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr488Asnfs*12) are predicted to truncate the protein, likely impairing zinc transport activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported for SLC30A6.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for SLC30A6.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005385 – zinc ion transmembrane transporter activity | • GO:0005794 – Golgi apparatus |
| • GO:0006829 – zinc ion transport | • GO:0071577 – zinc ion export from Golgi apparatus |
| • GO:0046873 – metal ion transmembrane transporter activity |
Pathways
• Zinc homeostasis (Reactome: R-HSA-435354)
• Metal ion SLC transporters (Reactome: R-HSA-425393)
Protein Summary
ZnT6 (UniProt Q6NXT4) is a 460-amino acid protein with six transmembrane domains. It localizes to the Golgi apparatus and functions as a zinc/proton antiporter, exporting zinc from the cytosol into the Golgi lumen. ZnT6 forms functional heterodimers with ZnT5 (SLC30A5) to achieve full transport activity. It is widely expressed, with highest levels in brain, pancreas, and prostate. Post-translational modifications include N-glycosylation at Asn-298.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC30A6 Knockout HEK293 Cell Line | EDC08078 | Human | 55676 | Details Get a Quote |
| SLC30A6 Knockout A-549 Cell Line | EDJ-KQ46035 | Human | 55676 | Details Get a Quote |
| SLC30A6 Knockout HCT 116 Cell Line | EDJ-KQ46036 | Human | 55676 | Details Get a Quote |
| SLC30A6 Knockout HeLa Cell Line | EDJ-KQ46037 | Human | 55676 | Details Get a Quote |
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