SLC2A7: Solute Carrier Family 2 Member 7
Glucose Transporter 7 (GLUT7) – A Facilitative Hexose Transporter with Potential Roles in Hepatic Glucose Metabolism
Gene Information Card
| Symbol | SLC2A7 |
|---|---|
| Full Name | Solute Carrier Family 2 Member 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.23 |
| NCBI Gene ID | 155184 ncbi.nlm.nih.gov/gene/155184 |
| Ensembl ID | ENSG00000197273 |
| UniProt ID | Q6P9F0 |
| OMIM ID | 610371 |
| HGNC ID | 13445 |
| Aliases | GLUT7, GLUT-7 |
Description
SLC2A7 (Solute Carrier Family 2 Member 7) encodes GLUT7, a facilitative glucose transporter belonging to the GLUT family. GLUT7 is a high-affinity transporter for glucose and fructose, predominantly expressed in the liver and small intestine. It is localized to the endoplasmic reticulum membrane and may play a role in hepatic glucose and fructose metabolism. The gene is located on chromosome 1p36.23 and is distinct from other GLUT isoforms in its subcellular localization and substrate specificity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Diabetes mellitus type 2 | Altered hepatic glucose transport may contribute to insulin resistance; GLUT7 expression changes observed in diabetic models | Limited; expression studies in rodent models |
| Non-alcoholic fatty liver disease (NAFLD) | Potential involvement in hepatic fructose uptake and lipogenesis | Expression correlation studies |
| Fructose malabsorption | Impaired fructose transport due to GLUT7 dysfunction | Hypothetical; no direct clinical evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 2.3 | Low |
| Small intestine | 1.8 | Low |
| Kidney | 0.5 | Not detected |
| Pancreas | 0.3 | Not detected |
| Skeletal muscle | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 1.5 | Hepatocellular carcinoma cell line |
| Caco-2 | 1.2 | Colorectal adenocarcinoma cell line |
| HEK293 | 0.4 | Embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | Unknown; predicted to affect transporter function |
| c.454C>T (p.Arg152Trp) | Missense | <0.01% | Unknown; predicted damaging by in silico tools |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations described.
Dominant Negative (DN)
No dominant-negative variants identified.
View complete mutation data：
Gene Ontology (GO)
| • glucose transmembrane transporter activity (GO:0005355) | • monosaccharide transmembrane transporter activity (GO:0015145) |
| • transmembrane transport (GO:0055085) | • plasma membrane (GO:0005886) |
| • endoplasmic reticulum (GO:0005783) |
Pathways
• Glucose transport (Reactome: R-HSA-189200)
• Fructose metabolism (KEGG: hsa00051)
Protein Summary
GLUT7 (UniProt Q6P9F0) is a 524-amino acid facilitative glucose/fructose transporter with 12 transmembrane domains. It shares ~68% sequence identity with GLUT5 and is localized to the endoplasmic reticulum membrane. GLUT7 has a high affinity for glucose (Km ~0.3 mM) and fructose (Km ~0.2 mM). Its expression is highest in liver and small intestine, suggesting a role in dietary sugar uptake and hepatic glucose homeostasis. No 3D structure has been solved experimentally.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC2A7 Knockout HEK293 Cell Line | EDJ-KQ15277 | Human | 155184 | Details Get a Quote |
| SLC2A7 Knockout HeLa Cell Line | EDJ-KQ58753 | Human | 155184 | Details Get a Quote |
| SLC2A7 Knockout A-549 Cell Line | EDJ-KQ67238 | Human | 155184 | Details Get a Quote |
| SLC2A7 Knockout HCT 116 Cell Line | EDJ-KQ75635 | Human | 155184 | Details Get a Quote |
