SLC2A6: Solute Carrier Family 2 Member 6
Glucose Transporter GLUT6: Gene, Function, and Clinical Relevance
Gene Information Card
| Symbol | SLC2A6 |
|---|---|
| Full Name | Solute Carrier Family 2 Member 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 9q34.2 |
| NCBI Gene ID | 11182 ncbi.nlm.nih.gov/gene/11182 |
| Ensembl ID | ENSG00000136997 |
| UniProt ID | Q9UGQ3 |
| OMIM ID | 606813 |
| HGNC ID | 11007 |
| Aliases | GLUT6, GLUT9 |
Description
SLC2A6 (Solute Carrier Family 2 Member 6) encodes the facilitative glucose transporter GLUT6. This protein belongs to the major facilitator superfamily of glucose transporters and mediates the uptake of glucose and other hexoses across cellular membranes. GLUT6 is predominantly expressed in brain, spleen, and leukocytes, and its expression is regulated in response to metabolic demands. The gene is located on chromosome 9q34.2 and spans approximately 8.5 kb.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Type 2 Diabetes | Altered glucose transport in insulin-sensitive tissues may contribute to insulin resistance. | PMID: 12588804 |
| Obesity | Dysregulation of GLUT6 expression in adipose tissue linked to metabolic syndrome. | PMID: 18334619 |
| Cancer (various) | Overexpression in certain tumors may support increased glycolytic metabolism (Warburg effect). | PMID: 22952472 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Medium |
| Spleen | 4.8 | Medium |
| Leukocytes | 3.9 | Low |
| Lung | 2.1 | Low |
| Liver | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 2.5 | Low expression |
| K562 | 4.1 | Moderate expression |
| HepG2 | 1.2 | Low expression |
| SH-SY5Y | 6.0 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045G>A (p.Gly349Arg) | Missense | <0.01% | Unknown functional effect |
| c.1273C>T (p.Arg425Trp) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • glucose transmembrane transporter activity (GO:0005355) | • glucose transport (GO:0015758) |
| • integral component of plasma membrane (GO:0005887) | • transmembrane transport (GO:0055085) |
Pathways
• REACT:14797 - Glucose transport
• WP:WP1570 - Glucose metabolism
• KEGG:hsa04931 - Insulin resistance
Protein Summary
GLUT6 is a 507-amino acid facilitative glucose transporter with 12 transmembrane domains. It shares ~40% sequence identity with GLUT1. The protein is N-glycosylated and localizes to the plasma membrane. GLUT6 has a low affinity for glucose (Km ~5 mM) and is inhibited by cytochalasin B. It may play a role in glucose sensing in the brain and immune cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC2A6 Knockout HEK293 Cell Line | EDJ-KQ7321 | Human | 11182 | Details Get a Quote |
| SLC2A6 Knockout HeLa Cell Line | EDJ-KQ18245 | Human | 11182 | Details Get a Quote |
| SLC2A6 Knockout A-549 Cell Line | EDJ-KQ32390 | Human | 11182 | Details Get a Quote |
| SLC2A6 Knockout HCT 116 Cell Line | EDC08629 | Human | 11182 | Details Get a Quote |
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