SLC26A11
Solute Carrier Family 26 Member 11
Gene Information Card
| Symbol | SLC26A11 |
|---|---|
| Full Name | solute carrier family 26 member 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 284129 ncbi.nlm.nih.gov/gene/284129 |
| Ensembl ID | ENSG00000182901 |
| UniProt ID | Q86WA9 |
| OMIM ID | 617617 |
| HGNC ID | 30188 |
| Aliases | SLC26A11, dJ1033B10.2 |
Description
SLC26A11 (solute carrier family 26 member 11) is a protein-coding gene located on chromosome 17q25.3. It encodes a member of the SLC26 family of anion transporters, which mediate the transport of sulfate, oxalate, chloride, and other anions across cellular membranes. SLC26A11 is widely expressed and involved in ion homeostasis and pH regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hearing loss | Potential role in inner ear anion transport; limited direct evidence | Inferred from family member SLC26A4 (Pendrin) and expression in cochlea |
| Renal tubular acidosis | Possible involvement in renal anion exchange; not confirmed | Hypothetical based on SLC26 family function |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Lung | 6.7 | Low |
| Brain | 4.2 | Low |
| Testis | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Moderate expression |
| HepG2 | 9.8 | Moderate expression |
| A549 | 7.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | missense | <0.01% | Unknown functional effect |
| c.457G>A (p.Val153Ile) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not established for SLC26A11; no confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • ammonium transmembrane transporter activity (GO:0008519) | • sulfate transmembrane transporter activity (GO:0015116) |
| • integral component of membrane (GO:0016021) | • transmembrane transport (GO:0055085) |
Pathways
• SLC26 family of anion transporters
• Sulfate transport (Reactome: R-HSA-428776)
Protein Summary
SLC26A11 encodes a 739-amino acid multi-pass membrane protein belonging to the SLC26 family. It functions as an anion transporter, likely mediating sulfate and chloride exchange. The protein is predicted to have 12 transmembrane domains and is localized to the plasma membrane. Its exact physiological role remains under investigation, but it is thought to contribute to ion homeostasis in kidney, liver, and other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC26A11 Knockout HEK293 Cell Line | EDJ-KQ15321 | Human | 284129 | Details Get a Quote |
| SLC26A11 Knockout A-549 Cell Line | EDJ-KQ46029 | Human | 284129 | Details Get a Quote |
| SLC26A11 Knockout HCT 116 Cell Line | EDJ-KQ46030 | Human | 284129 | Details Get a Quote |
| SLC26A11 Knockout HeLa Cell Line | EDJ-KQ44812 | Human | 284129 | Details Get a Quote |
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