SLC25A36: Solute Carrier Family 25 Member 36
Mitochondrial nucleotide transporter with roles in metabolism and cancer
Gene Information Card
| Symbol | SLC25A36 |
|---|---|
| Full Name | Solute Carrier Family 25 Member 36 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q22.1 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000114126 |
| UniProt ID | Q9BRJ6 |
| OMIM ID | 610815 |
| HGNC ID | 23218 |
| Aliases | FLJ10618, MGC138499, MGC138500, PNAS-137 |
Description
SLC25A36 (Solute Carrier Family 25 Member 36) encodes a mitochondrial inner membrane transporter that mediates the exchange of nucleotides, particularly ATP and ADP, across the mitochondrial membrane. It plays a critical role in cellular energy homeostasis and nucleotide pool balance. The gene is widely expressed and has been implicated in metabolic disorders and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Overexpression promotes proliferation and metastasis via altered nucleotide transport | COSMIC, PubMed |
| Hepatocellular carcinoma | Upregulation correlates with poor prognosis and metabolic reprogramming | COSMIC, PubMed |
| Breast cancer | Dysregulation linked to mitochondrial dysfunction and chemoresistance | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.8 | Medium |
| Heart | 8.2 | Medium |
| Brain | 6.1 | Low |
| Lung | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.3 | Hepatocellular carcinoma |
| HeLa | 11.7 | Cervical adenocarcinoma |
| A549 | 9.2 | Lung carcinoma |
| MCF7 | 7.8 | Breast adenocarcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104C>T (p.Pro35Leu) | Missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Val153Ile) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005471 - ATP:ADP antiporter activity | • GO:0015216 - purine nucleotide transmembrane transporter activity |
| • GO:0015217 - ADP transmembrane transporter activity | • GO:0015218 - ATP transmembrane transporter activity |
| • GO:0005743 - mitochondrial inner membrane | • GO:0005739 - mitochondrion |
| • GO:0055085 - transmembrane transport |
Pathways
• Mitochondrial nucleotide transport
• Purine metabolism
• Energy metabolism
Protein Summary
SLC25A36 is a 320-amino acid mitochondrial inner membrane protein belonging to the SLC25 family of solute carriers. It functions as an ATP/ADP antiporter, exchanging cytosolic ADP for mitochondrial ATP, thereby linking mitochondrial oxidative phosphorylation to cellular energy demands. The protein contains three tandem repeats of a characteristic mitochondrial carrier domain. Its expression is regulated in response to metabolic stress and has been associated with tumor growth and survival.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC25A36 Knockout HEK293 Cell Line | EDJ-KQ15312 | Human | 55186 | Details Get a Quote |
| SLC25A36 Knockout A-549 Cell Line | EDJ-KQ46015 | Human | 55186 | Details Get a Quote |
| SLC25A36 Knockout HCT 116 Cell Line | EDC08390 | Human | 55186 | Details Get a Quote |
| SLC25A36 Knockout HeLa Cell Line | EDJ-KQ46017 | Human | 55186 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
