SLC25A35 Gene - Solute Carrier Family 25 Member 35
Comprehensive resource for SLC25A35 (solute carrier family 25 member 35), including genomic information, expression, mutations, and more.
Gene Information Card
| Symbol | SLC25A35 |
|---|---|
| Full Name | solute carrier family 25 member 35 |
| Gene Type | gene with protein product |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 399512 ncbi.nlm.nih.gov/gene/399512 |
| Ensembl ID | ENSG00000125434 |
| UniProt ID | Q3KQZ1 |
| OMIM ID | 610818 |
| HGNC ID | HGNC:31921 |
| Aliases | FLJ40217 |
Description
SLC25A35 (solute carrier family 25 member 35) is a protein-coding gene located on chromosome 17p13.1. It encodes a member of the SLC25 family of mitochondrial carrier proteins, which are involved in the transport of metabolites across the mitochondrial inner membrane. The specific function of SLC25A35 is not fully characterized, but it is predicted to play a role in mitochondrial transport processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific diseases associated | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Kidney | 3.1 | Low |
| Liver | 2.8 | Low |
| Brain | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 2.0 | Low expression |
| HeLa | 1.5 | Low expression |
| HepG2 | 1.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No clinically significant variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No known loss-of-function mutations reported.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • mitochondrial transport | • transmembrane transport |
| • integral component of membrane | • mitochondrial inner membrane |
Pathways
• Mitochondrial transport
Protein Summary
The SLC25A35 protein is a member of the mitochondrial carrier family (SLC25). It is predicted to be localized to the mitochondrial inner membrane and may function as a transporter for various metabolites. However, its exact substrate and physiological role remain to be elucidated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC25A35 Knockout HEK293 Cell Line | EDJ-KQ15311 | Human | 399512 | Details Get a Quote |
| SLC25A35 Knockout HCT 116 Cell Line | EDJ-KQ46013 | Human | 399512 | Details Get a Quote |
| SLC25A35 Knockout HeLa Cell Line | EDJ-KQ46014 | Human | 399512 | Details Get a Quote |
| SLC25A35 Knockout A-549 Cell Line | EDJ-KQ48203 | Human | 399512 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
