SLC25A34 Gene - Solute Carrier Family 25 Member 34
Comprehensive genomic and proteomic information for SLC25A34, a mitochondrial solute carrier.
Gene Information Card
| Symbol | SLC25A34 |
|---|---|
| Full Name | solute carrier family 25 member 34 |
| Gene Type | gene with protein product |
| Chromosomal Location | 1p36.21 |
| NCBI Gene ID | 284723 ncbi.nlm.nih.gov/gene/284723 |
| Ensembl ID | ENSG00000162461 |
| UniProt ID | Q6PIV7 |
| OMIM ID | 610817 |
| HGNC ID | HGNC:27653 |
| Aliases | DKFZp781A10161 |
Description
SLC25A34 (solute carrier family 25 member 34) is a protein-coding gene located on chromosome 1p36.21. It encodes a member of the SLC25 family of mitochondrial carrier proteins, which are involved in transporting various metabolites across the mitochondrial inner membrane. The specific function of SLC25A34 is not fully characterized, but it is predicted to play a role in mitochondrial metabolism. Expression data indicate broad tissue distribution with highest levels in the liver and kidney.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations have been established for SLC25A34. | Not applicable | No curated disease associations in OMIM or ClinVar. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Kidney | 10.1 | Medium |
| Testis | 8.5 | Low |
| Brain | 5.2 | Low |
| Heart | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| A549 | 8.7 | Lung carcinoma cell line |
| HeLa | 6.3 | Cervical adenocarcinoma cell line |
| K562 | 4.1 | Chronic myelogenous leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No clinically significant variants have been reported in SLC25A34. | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations have been characterized.
Gain of Function (GOF)
No gain-of-function mutations have been characterized.
Dominant Negative (DN)
No dominant-negative mutations have been characterized.
View complete mutation data：
Gene Ontology (GO)
| • mitochondrial inner membrane | • transmembrane transport |
| • integral component of membrane |
Pathways
• Mitochondrial transport
Protein Summary
The SLC25A34 protein is a member of the SLC25 family of mitochondrial carrier proteins. It is predicted to be localized to the mitochondrial inner membrane and may function as a transporter of small molecules. The exact substrate and physiological role remain to be determined. The protein is expressed in various tissues, with higher levels in liver and kidney, suggesting a role in metabolic processes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC25A34 Knockout HEK293 Cell Line | EDJ-KQ15310 | Human | 284723 | Details Get a Quote |
| SLC25A34 Knockout HeLa Cell Line | EDJ-KQ59489 | Human | 284723 | Details Get a Quote |
| SLC25A34 Knockout A-549 Cell Line | EDJ-KQ67957 | Human | 284723 | Details Get a Quote |
| SLC25A34 Knockout HCT 116 Cell Line | EDJ-KQ76334 | Human | 284723 | Details Get a Quote |
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