SLC22A9
Solute Carrier Family 22 Member 9
Gene Information Card
| Symbol | SLC22A9 |
|---|---|
| Full Name | Solute Carrier Family 22 Member 9 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 114571 ncbi.nlm.nih.gov/gene/114571 |
| Ensembl ID | ENSG00000149295 |
| UniProt ID | Q8IVM8 |
| OMIM ID | 607580 |
| HGNC ID | 18122 |
| Aliases | OAT7, hOAT7, FLJ22362 |
Description
SLC22A9 encodes the organic anion transporter 7 (OAT7), a member of the solute carrier family 22. OAT7 mediates the sodium-independent transport of organic anions such as estrone sulfate, dehydroepiandrosterone sulfate (DHEAS), and sulfated steroids. It is primarily expressed in the liver and kidney and plays a role in the renal and hepatic clearance of endogenous and exogenous organic anions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Primary hyperoxaluria type I | Potential involvement in oxalate transport; limited evidence | UniProt annotation; not confirmed in ClinVar |
| Chronic kidney disease | Altered OAT7 expression may affect uremic toxin clearance | NCBI GeneRIF; PMID: 21976557 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Small intestine | 2.1 | Low |
| Colon | 1.0 | Low |
| Testis | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 5.2 | Hepatocellular carcinoma cell line |
| HK-2 | 3.8 | Proximal tubule epithelial cell line |
| Caco-2 | 1.1 | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.124G>A (p.Gly42Arg) | missense | <0.01% | Unknown functional effect |
| c.457C>T (p.Arg153Trp) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0015171 – amino acid transmembrane transporter activity | • GO:0015297 – antiporter activity |
| • GO:0015711 – organic anion transport | • GO:0016021 – integral component of membrane |
| • GO:0055085 – transmembrane transport |
Pathways
• Organic anion transport (Reactome: R-HSA-561910)
• SLC-mediated transmembrane transport (Reactome: R-HSA-425407)
Protein Summary
OAT7 is a 556-amino acid transmembrane protein with 12 predicted alpha-helical domains. It functions as an organic anion exchanger, coupling the uptake of sulfated steroids with the efflux of monocarboxylates such as lactate. OAT7 is localized to the basolateral membrane of hepatocytes and the apical membrane of renal proximal tubule cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC22A9 Knockout HEK293 Cell Line | EDJ-KQ7445 | Human | 114571 | Details Get a Quote |
| SLC22A9 Knockout HeLa Cell Line | EDJ-KQ57922 | Human | 114571 | Details Get a Quote |
| SLC22A9 Knockout A-549 Cell Line | EDJ-KQ66413 | Human | 114571 | Details Get a Quote |
| SLC22A9 Knockout HCT 116 Cell Line | EDJ-KQ74838 | Human | 114571 | Details Get a Quote |
| SLC22A9 Knockout Huh-7 Cell Line | EDC08329 | Human | 114571 | Details Get a Quote |
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