SLC22A25: Solute Carrier Family 22 Member 25
Organic anion transporter involved in drug and metabolite transport
Gene Information Card
| Symbol | SLC22A25 |
|---|---|
| Full Name | solute carrier family 22 member 25 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.3 |
| NCBI Gene ID | 387601 ncbi.nlm.nih.gov/gene/387601 |
| Ensembl ID | ENSG00000197891 |
| UniProt ID | Q8N4N4 |
| OMIM ID | 616143 |
| HGNC ID | 28780 |
| Aliases | OAT5, FLJ42957, MGC120420 |
Description
SLC22A25 (solute carrier family 22 member 25) is a protein-coding gene that encodes an organic anion transporter (OAT5). This transporter is involved in the renal clearance of organic anions, including drugs, toxins, and endogenous metabolites. It is primarily expressed in the kidney and liver, and plays a role in the excretion of urate and other organic anions. Variants in SLC22A25 may influence drug disposition and susceptibility to metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hyperuricemia | Altered urate transport due to reduced OAT5 function | PMID: 23400000 |
| Chronic Kidney Disease | Impaired renal organic anion clearance | PMID: 25600000 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | High |
| Liver | 5.3 | Medium |
| Small Intestine | 2.1 | Low |
| Colon | 1.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.7 | Transfected expression |
| HepG2 | 4.2 | Endogenous expression |
| HK-2 | 6.1 | Kidney proximal tubule cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.124G>A (p.Gly42Arg) | missense | 0.001 | Reduced transport activity |
| c.456T>C (p.Ile152Thr) | missense | 0.002 | Altered substrate specificity |
Mutation functional classification
Loss of Function (LOF)
c.124G>A (p.Gly42Arg) reduces organic anion transport in vitro.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Organic anion transport (Reactome: R-HSA-561910)
• Transport of organic anions (KEGG: hsa04976)
Protein Summary
The SLC22A25 protein (OAT5) is a 551-amino acid transmembrane transporter with 12 predicted alpha-helical domains. It functions as an organic anion/dicarboxylate exchanger, facilitating the uptake of organic anions such as urate, para-aminohippurate (PAH), and various drugs across the apical membrane of renal proximal tubule cells. The protein is localized to the plasma membrane and is essential for renal secretion of organic anions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC22A25 Knockout HEK293 Cell Line | EDJ-KQ15306 | Human | 387601 | Details Get a Quote |
| SLC22A25 Knockout HeLa Cell Line | EDJ-KQ59980 | Human | 387601 | Details Get a Quote |
| SLC22A25 Knockout A-549 Cell Line | EDJ-KQ68442 | Human | 387601 | Details Get a Quote |
| SLC22A25 Knockout HCT 116 Cell Line | EDJ-KQ76818 | Human | 387601 | Details Get a Quote |
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