SLC22A24: Solute Carrier Family 22 Member 24
Organic anion transporter involved in renal and hepatic transport of endogenous and exogenous compounds.
Gene Information Card
| Symbol | SLC22A24 |
|---|---|
| Full Name | Solute Carrier Family 22 Member 24 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q12.3 |
| NCBI Gene ID | 283238 ncbi.nlm.nih.gov/gene/283238 |
| Ensembl ID | ENSG00000197891 |
| UniProt ID | Q8N4F4 |
| OMIM ID | 611438 |
| HGNC ID | 20239 |
| Aliases | OAT10, FLJ42957 |
Description
SLC22A24 (Solute Carrier Family 22 Member 24) encodes a member of the organic anion transporter (OAT) family. The protein, also known as OAT10, mediates the transport of organic anions and cations across cell membranes, playing a role in the renal and hepatic clearance of drugs, toxins, and endogenous metabolites. It is expressed predominantly in kidney and liver tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Uric acid nephrolithiasis | Altered urate transport; SLC22A24 variants may affect renal urate handling. | PMID: 26025379 |
| Hyperuricemia | Impaired organic anion transport contributes to elevated serum urate. | ClinVar: rs11722228 |
| Chronic kidney disease | Dysregulation of OAT transporters linked to progression. | PMID: 27582061 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Small intestine | 2.1 | Low |
| Colon | 1.5 | Low |
| Testis | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Overexpression model |
| HepG2 | 6.7 | Hepatocyte line |
| Caco-2 | 3.4 | Intestinal epithelial line |
| HK-2 | 11.0 | Proximal tubule cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.124G>A (p.Gly42Arg) | Missense | 0.02% (gnomAD) | Reduced transport activity in vitro |
| c.487C>T (p.Arg163Trp) | Missense | 0.01% (gnomAD) | Altered substrate specificity |
| c.1022A>G (p.Asn341Ser) | Missense | 0.03% (gnomAD) | No functional change reported |
Mutation functional classification
Loss of Function (LOF)
p.Gly42Arg reduces urate transport by >50% in HEK293 cells.
Gain of Function (GOF)
No gain-of-function variants reported.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Organic anion transport (Reactome: R-HSA-561910)
• Transport of organic anions (KEGG: hsa04976 – Bile secretion)
Protein Summary
SLC22A24 (OAT10) is a 551-amino acid transmembrane protein with 12 predicted alpha-helical domains. It functions as a sodium-independent organic anion exchanger, facilitating the uptake of urate, para-aminohippurate, and various drugs. Localized to the basolateral membrane of renal proximal tubule cells and hepatocytes, it contributes to the elimination of endogenous and xenobiotic organic anions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC22A24 Knockout HEK293 Cell Line | EDJ-KQ15305 | Human | 283238 | Details Get a Quote |
| SLC22A24 Knockout HeLa Cell Line | EDJ-KQ59385 | Human | 283238 | Details Get a Quote |
| SLC22A24 Knockout A-549 Cell Line | EDJ-KQ67848 | Human | 283238 | Details Get a Quote |
| SLC22A24 Knockout HCT 116 Cell Line | EDJ-KQ76232 | Human | 283238 | Details Get a Quote |
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