SLC22A15 Gene: Function, Expression, and Clinical Significance

SLC22A15 (solute carrier family 22 member 15) is a protein-coding gene located on chromosome 1p13.1. It encodes a member of the solute carrier family 22, which includes organic cation and anion transporters. SLC22A15 is also known as FLIPT1 (Fly-like putative transporter 1). The protein is predicted to be a transmembrane transporter involved in the transport of organic cations and possibly other substrates. SLC22A15 is expressed in various tissues, with notable expression in the kidney, liver, and brain. Its function is not fully characterized, but it may play a role in drug transport and metabolism. Mutations in SLC22A15 have been associated with certain diseases, and its expression is altered in some cancers.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Solute carrier (SLC) transporter family

• Organic cation transport

The SLC22A15 protein is a predicted multi-pass membrane protein belonging to the SLC22 family. It is likely involved in the transport of organic cations across cell membranes. The protein is expressed in various tissues, with higher levels in kidney and liver, suggesting a role in renal and hepatic clearance of endogenous and exogenous compounds. Its exact substrates and physiological functions remain to be fully characterized, but it may contribute to drug disposition and detoxification processes.