SLC22A15
Solute Carrier Family 22 Member 15
Gene Information Card
| Symbol | SLC22A15 |
|---|---|
| Full Name | Solute Carrier Family 22 Member 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p13.1 |
| NCBI Gene ID | 55356 ncbi.nlm.nih.gov/gene/55356 |
| Ensembl ID | ENSG00000163399 |
| UniProt ID | Q8N2K0 |
| OMIM ID | 616083 |
| HGNC ID | 18118 |
| Aliases | FLJ20156, MGC138290, OCTL3, hOCTL3 |
Description
SLC22A15 encodes a member of the solute carrier family 22 (SLC22) of organic cation transporters. The protein is involved in the transport of organic cations, including endogenous metabolites and xenobiotics, across cellular membranes. It is expressed in various tissues, with highest levels in kidney and liver, and may play a role in drug disposition and metabolic homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Not directly associated with specific diseases | Limited evidence; potential involvement in drug metabolism and transport | No direct disease association reported in OMIM or ClinVar as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Small intestine | 6.1 | Low |
| Brain | 2.4 | Low |
| Heart | 1.8 | Low |
| Kidney | High (e.g., ~30-40 nTPM) | High expression in renal tubules |
| Liver | Moderate (e.g., ~15-20 nTPM) | Hepatocyte expression |
| Small intestine | Moderate (e.g., ~10-15 nTPM) | Enterocyte expression |
| Brain | Low (e.g., <5 nTPM) | Minimal expression |
| Lung | Low (e.g., <5 nTPM) | Minimal expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression |
| HepG2 | 9.7 | Medium expression |
| Caco-2 | 5.3 | Low expression |
| SH-SY5Y | 2.1 | Low expression |
| HepG2 | ~20 nTPM | Liver cancer cell line |
| HK-2 | ~35 nTPM | Kidney proximal tubular cell line |
| Caco-2 | ~15 nTPM | Intestinal epithelial cell line |
| A549 | ~5 nTPM | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs11568643 | SNV (missense) | Minor allele frequency ~0.05 (global) | Amino acid substitution; functional impact not fully characterized |
| rs11568644 | SNV (synonymous) | Minor allele frequency ~0.10 | No amino acid change; likely benign |
| rs11568645 | SNV (missense) | Minor allele frequency ~0.02 | Potential alteration in transport activity; not clinically validated |
Mutation functional classification
Loss of Function (LOF)
Gain of Function (GOF)
Dominant Negative (DN)
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC for SLC22A15.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Protein Summary
The SLC22A15 protein is a 551-amino acid transmembrane transporter with 12 predicted alpha-helical domains. It belongs to the major facilitator superfamily and mediates the uptake of organic cations such as tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+). The protein is localized to the plasma membrane and is involved in renal and hepatic clearance of cationic drugs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC22A15 Knockout HEK293 Cell Line | EDJ-KQ14511 | Human | 55356 | Details Get a Quote |
| SLC22A15 Knockout A-549 Cell Line | EDJ-KQ45999 | Human | 55356 | Details Get a Quote |
| SLC22A15 Knockout HCT 116 Cell Line | EDJ-KQ46000 | Human | 55356 | Details Get a Quote |
| SLC22A15 Knockout HeLa Cell Line | EDJ-KQ46001 | Human | 55356 | Details Get a Quote |
| SLC22A15 Knockout Huh-7 Cell Line | EDC07816 | Human | 55356 | Details Get a Quote |
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