SLC22A10
Solute Carrier Family 22 Member 10
Gene Information Card
| Symbol | SLC22A10 |
|---|---|
| Full Name | Solute Carrier Family 22 Member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 6q27 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | Q63ZE4 |
| OMIM ID | 191170 |
| HGNC ID | 10970 |
| Aliases | OAT5, hOAT5, organic anion transporter 5 |
Description
SLC22A10 encodes a member of the solute carrier family 22 (organic anion transporter) subfamily. The encoded protein, OAT5, mediates the sodium-independent transport of organic anions such as estrone sulfate, dehydroepiandrosterone sulfate, and other sulfated conjugates. It is primarily expressed in the kidney and liver and may play a role in the renal clearance of endogenous and exogenous organic anions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations currently curated in ClinVar or OMIM | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.3 | Medium |
| Liver | 8.7 | Low |
| Small intestine | 2.1 | Not detected |
| Colon | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | No endogenous expression |
| HepG2 | 0.0 | No endogenous expression |
| HK-2 | 0.0 | No endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No functional data available
Gain of Function (GOF)
No functional data available
Dominant Negative (DN)
No functional data available
View complete mutation data：
Gene Ontology (GO)
| • GO:0008514 – organic anion transmembrane transporter activity | • GO:0015293 – symporter activity |
| • GO:0016021 – integral component of membrane | • GO:0055085 – transmembrane transport |
Pathways
• Organic anion transport (Reactome: R-HSA-561910)
• Transport of inorganic cations/anions/amino acids/oligopeptides (Reactome: R-HSA-425393)
Protein Summary
SLC22A10 (OAT5) is a 551-amino acid transmembrane protein with 12 predicted transmembrane domains. It functions as an organic anion transporter, facilitating the uptake of sulfated steroid conjugates. The protein is localized to the plasma membrane and is expressed in kidney proximal tubules and liver. No disease-associated variants have been validated to date.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC22A10 Knockout HEK293 Cell Line | EDJ-KQ7446 | Human | 387775 | Details Get a Quote |
| SLC22A10 Knockout HeLa Cell Line | EDJ-KQ59992 | Human | 387775 | Details Get a Quote |
| SLC22A10 Knockout A-549 Cell Line | EDJ-KQ68454 | Human | 387775 | Details Get a Quote |
| SLC22A10 Knockout HCT 116 Cell Line | EDJ-KQ76831 | Human | 387775 | Details Get a Quote |
| SLC22A10 Knockout Huh-7 Cell Line | EDC08263 | Human | 387775 | Details Get a Quote |
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