SLC16A5: Solute Carrier Family 16 Member 5
Monocarboxylate Transporter 6 (MCT6) – A Key Transporter in Drug Disposition and Metabolic Homeostasis
Gene Information Card
| Symbol | SLC16A5 |
|---|---|
| Full Name | Solute Carrier Family 16 Member 5 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q25.1 |
| NCBI Gene ID | 9121 ncbi.nlm.nih.gov/gene/9121 |
| Ensembl ID | ENSG00000170190 |
| UniProt ID | Q9Y6R1 |
| OMIM ID | 603654 |
| HGNC ID | 10925 |
| Aliases | MCT6, MCT-6 |
Description
SLC16A5 (Solute Carrier Family 16 Member 5) encodes monocarboxylate transporter 6 (MCT6), a proton-coupled transporter of monocarboxylates such as lactate, pyruvate, and ketone bodies. MCT6 is involved in cellular metabolic waste removal, drug disposition, and pH regulation. It is expressed in various tissues including kidney, skeletal muscle, and placenta, and plays a role in the transport of xenobiotics and endogenous metabolites.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lactic Acidosis (secondary) | Impaired lactate transport due to SLC16A5 dysfunction may contribute to metabolic acidosis | Case reports, functional studies |
| Drug-induced toxicity (e.g., statin myopathy) | Altered transporter activity affects drug clearance and tissue accumulation | Pharmacogenetic association studies |
| Cancer (various types) | Dysregulated MCT6 expression influences tumor metabolism and microenvironment | Expression profiling, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Skeletal Muscle | 8.3 | Medium |
| Placenta | 7.1 | Medium |
| Liver | 4.2 | Low |
| Heart | 3.8 | Low |
| Brain | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression |
| HepG2 | 6.8 | Moderate expression |
| Caco-2 | 4.5 | Low expression |
| MCF7 | 2.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.01% | Reduced transport activity in vitro |
| c.567G>A (p.Val189Met) | Missense | <0.01% | Altered substrate specificity |
| c.890_891insA | Frameshift | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations leading to truncated protein or reduced transport capacity.
Gain of Function (GOF)
Not reported for SLC16A5.
Dominant Negative (DN)
Not reported for SLC16A5.
View complete mutation data：
Gene Ontology (GO)
| • amino acid transmembrane transporter activity (GO:0015171) | • symporter activity (GO:0015293) |
| • monocarboxylate transport (GO:0015718) | • organic acid transport (GO:0015849) |
| • integral component of plasma membrane (GO:0005887) |
Pathways
• Transport of monocarboxylates (Reactome: R-HSA-433137)
• SLC-mediated transmembrane transport (Reactome: R-HSA-425407)
Protein Summary
MCT6 (UniProt Q9Y6R1) is a 12-transmembrane domain protein that functions as a proton-coupled monocarboxylate transporter. It facilitates the bidirectional movement of lactate, pyruvate, and ketone bodies across the plasma membrane. MCT6 is expressed in kidney, skeletal muscle, and placenta, and is involved in drug transport, particularly of statins and other organic anions. Its activity is pH-dependent and essential for metabolic homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC16A5 Knockout HEK293 Cell Line | EDJ-KQ5798 | Human | 9121 | Details Get a Quote |
| SLC16A5 Knockout A-549 Cell Line | EDJ-KQ30552 | Human | 9121 | Details Get a Quote |
| SLC16A5 Knockout HCT 116 Cell Line | EDJ-KQ30554 | Human | 9121 | Details Get a Quote |
| SLC16A5 Knockout HeLa Cell Line | EDJ-KQ30555 | Human | 9121 | Details Get a Quote |
