SLC16A14
Solute Carrier Family 16 Member 14
Gene Information Card
| Symbol | SLC16A14 |
|---|---|
| Full Name | Solute Carrier Family 16 Member 14 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q36.3 |
| NCBI Gene ID | 151473 ncbi.nlm.nih.gov/gene/151473 |
| Ensembl ID | ENSG00000163082 |
| UniProt ID | Q7Z7M0 |
| OMIM ID | 611791 |
| HGNC ID | 26462 |
| Aliases | MCT14, MCT-14 |
Description
SLC16A14 (Solute Carrier Family 16 Member 14) is a protein-coding gene that encodes a member of the monocarboxylate transporter (MCT) family. The encoded protein is predicted to transport monocarboxylates such as lactate, pyruvate, and ketone bodies across the plasma membrane. SLC16A14 is expressed in various tissues and may play a role in metabolic processes and cellular pH regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression may influence tumor metabolism via lactate transport; limited direct evidence. | Expression studies; COSMIC mutation data |
| Metabolic disorders | Potential role in monocarboxylate transport dysregulation; not yet confirmed in specific diseases. | Inferred from gene family function |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Lung | 3.8 | Low |
| Liver | 2.1 | Low |
| Kidney | 4.0 | Low |
| Testis | 6.5 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.5 | Moderate expression |
| HeLa | 3.2 | Low expression |
| A549 | 2.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | missense | <0.01% | Unknown functional effect |
| c.452G>A (p.Arg151His) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • amino acid transmembrane transporter activity (GO:0015171) | • symporter activity (GO:0015293) |
| • monocarboxylic acid transport (GO:0015849) | • integral component of membrane (GO:0016021) |
Pathways
• Monocarboxylate transport (Reactome: R-HSA-433692)
Protein Summary
The SLC16A14 protein (UniProt Q7Z7M0) is a predicted 14-transmembrane domain transporter belonging to the monocarboxylate transporter family. It is thought to facilitate the proton-coupled transport of monocarboxylates across cell membranes. The protein is expressed in multiple tissues, with highest levels in testis. Its precise physiological substrates and functions remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC16A14 Knockout HEK293 Cell Line | EDJ-KQ11339 | Human | 151473 | Details Get a Quote |
| SLC16A14 Knockout A-549 Cell Line | EDJ-KQ39501 | Human | 151473 | Details Get a Quote |
| SLC16A14 Knockout HCT 116 Cell Line | EDJ-KQ39502 | Human | 151473 | Details Get a Quote |
| SLC16A14 Knockout HeLa Cell Line | EDJ-KQ39503 | Human | 151473 | Details Get a Quote |
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