SLC10A5
Solute Carrier Family 10 Member 5
Gene Information Card
| Symbol | SLC10A5 |
|---|---|
| Full Name | Solute Carrier Family 10 Member 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 8q21.13 |
| NCBI Gene ID | 347738 ncbi.nlm.nih.gov/gene/347738 |
| Ensembl ID | ENSG00000178573 |
| UniProt ID | Q5PT55 |
| OMIM ID | 617484 |
| HGNC ID | 22908 |
| Aliases | P5, NTCP2 |
Description
SLC10A5 encodes a member of the solute carrier family 10, which functions as a sodium-dependent bile acid transporter. The protein is involved in the transport of bile acids and other organic anions across cell membranes. Expression is primarily in the liver and kidney.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cholestasis | Impaired bile acid transport due to SLC10A5 dysfunction | Inferred from functional studies (UniProt) |
| Hypercholanemia | Potential role in bile acid homeostasis | Inferred from gene family homology (OMIM) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Kidney | 8.7 | Low |
| Small Intestine | 5.1 | Low |
| Testis | 2.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.5 | Hepatocyte model |
| HEK293 | 1.2 | Low expression |
| Caco-2 | 3.8 | Intestinal model |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown (rare variant) |
| c.245C>T | missense | <0.01% | Unknown (rare variant) |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • bile acid:sodium symporter activity (GO:0008508) | • bile acid transport (GO:0015721) |
| • integral component of membrane (GO:0016021) |
Pathways
• Bile acid and bile salt metabolism (Reactome: R-HSA-194068)
Protein Summary
SLC10A5 is a 349-amino acid transmembrane protein with 7 predicted helices. It belongs to the sodium/bile acid cotransporter family and is localized to the plasma membrane. The protein mediates sodium-dependent uptake of bile acids, contributing to enterohepatic circulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC10A5 Knockout HEK293 Cell Line | EDJ-KQ12163 | Human | 347051 | Details Get a Quote |
| SLC10A5 Knockout HCT 116 Cell Line | EDJ-KQ40865 | Human | 347051 | Details Get a Quote |
| SLC10A5 Knockout HeLa Cell Line | EDJ-KQ59807 | Human | 347051 | Details Get a Quote |
| SLC10A5 Knockout A-549 Cell Line | EDJ-KQ68274 | Human | 347051 | Details Get a Quote |
