SLAMF9 Gene: Function, Expression, and Disease Associations | Biomedical Resource

SLAMF9 (Signaling Lymphocytic Activation Molecule Family Member 9) is a type I transmembrane protein belonging to the CD2/SLAM family of immune receptors. It is characterized by an extracellular immunoglobulin-like domain and a cytoplasmic tail lacking classical signaling motifs. SLAMF9 is primarily expressed on myeloid cells, including monocytes, macrophages, and dendritic cells, and has been implicated in the regulation of inflammatory responses and tumor immunity. Unlike other SLAM family members, SLAMF9 does not bind SAP (SLAM-associated protein) and may signal through alternative pathways. Recent studies suggest a role in modulating cytokine production and phagocytosis, with potential implications in infectious diseases and cancer.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Immune system (Reactome: R-HSA-168256)

• Innate Immune System (Reactome: R-HSA-168249)

• Cytokine signaling in immune system (Reactome: R-HSA-1280215)

SLAMF9 is a 299-amino acid type I membrane protein with a single extracellular Ig-like V-type domain, a transmembrane region, and a short cytoplasmic tail. It lacks the immunoreceptor tyrosine-based switch motifs (ITSMs) typical of other SLAM family members, suggesting distinct signaling. The protein is glycosylated and may form homodimers. SLAMF9 is expressed on myeloid cells and is upregulated upon activation. It interacts with unknown ligands and may modulate TLR signaling, influencing cytokine secretion and phagocytosis. Structural studies are limited; however, its extracellular domain shares homology with other SLAM receptors.