SLAMF8 Gene: Function, Expression, and Role in Disease | NCBI, UniProt, OMIM

SLAMF8 (SLAM family member 8), also known as CD353, is a protein-coding gene located on chromosome 1q23.2. It encodes a type I transmembrane protein belonging to the signaling lymphocytic activation molecule (SLAM) family, which is involved in immune cell regulation. SLAMF8 is expressed predominantly on hematopoietic cells and plays a role in modulating inflammatory responses, particularly in macrophages and neutrophils. Its expression is upregulated in various inflammatory conditions and certain hematological malignancies. The gene has been implicated in autoimmune diseases and cancer through its effects on immune cell signaling.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• SLAM family signaling pathway (Reactome: R-HSA-2424491)

• NF-kappa B signaling pathway (KEGG: hsa04064)

• Toll-like receptor signaling pathway (KEGG: hsa04620)

SLAMF8 (CD353) is a 285-amino-acid type I transmembrane glycoprotein with a single extracellular Ig-like domain and a cytoplasmic tail containing immunoreceptor tyrosine-based switch motifs (ITSMs). It is primarily expressed on hematopoietic cells, including macrophages, neutrophils, and B cells. SLAMF8 functions as a co-receptor modulating immune cell activation, often promoting pro-inflammatory responses. Its expression is induced by inflammatory stimuli such as LPS and IFN-γ. The protein interacts with adaptor molecules like SAP and EAT-2 to transduce signals. SLAMF8 has been implicated in the pathogenesis of autoimmune diseases (e.g., rheumatoid arthritis, SLE) and hematological malignancies (e.g., AML).