SLAMF1 Gene: Function, Expression, and Disease Associations

SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1), also known as CD150, is a cell surface glycoprotein belonging to the immunoglobulin superfamily. It is expressed on hematopoietic cells and functions as a co-stimulatory receptor in immune responses. SLAMF1 serves as the primary receptor for measles virus entry into host cells. It is involved in T-cell and B-cell activation, cytokine production, and natural killer cell regulation. Mutations and altered expression of SLAMF1 are associated with lymphoproliferative disorders and autoimmune diseases.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• SLAM family signaling pathway (Reactome: R-HSA-2132295)

• Measles virus infection (KEGG: hsa05162)

• Adaptive immune system (Reactome: R-HSA-1280218)

SLAMF1 is a type I transmembrane protein with an extracellular region containing two immunoglobulin-like domains (V-set and C2-set) and a cytoplasmic tail with immunoreceptor tyrosine-based switch motifs (ITSMs). It is expressed primarily on hematopoietic cells and functions as a self-ligand receptor, mediating homophilic adhesion and co-stimulatory signals. Upon ligand binding, SLAMF1 recruits SH2-domain-containing proteins such as SAP (SH2D1A) and SHP-2, modulating immune cell activation. It is also exploited by measles virus as a receptor for entry into host cells.