SKIC8: SKI8 Subunit of Superkiller Complex
A component of the SKI complex involved in RNA exosome function and 3'-5' RNA degradation.
Gene Information Card
| Symbol | SKIC8 |
|---|---|
| Full Name | SKI8 subunit of superkiller complex |
| Gene Type | protein-coding |
| Chromosomal Location | 15q14 |
| NCBI Gene ID | 80222 ncbi.nlm.nih.gov/gene/80222 |
| Ensembl ID | ENSG00000137807 |
| UniProt ID | Q9Y2S7 |
| OMIM ID | 615596 |
| HGNC ID | 29163 |
| Aliases | SKI8, WDR61, MGC13170 |
Description
SKIC8 encodes a component of the SKI complex, which is essential for 3'-5' RNA degradation by the RNA exosome. The SKI complex facilitates the unwinding of RNA substrates and their delivery to the exosome. SKIC8 is also involved in other cellular processes including transcription and cell cycle regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | N/A | N/A |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 8.2 | Low |
| Lung | 6.1 | Low |
| Brain | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.3 | Moderate expression |
| HeLa | 8.7 | Low expression |
| K562 | 7.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • 3'-5' exoribonuclease activity |
| • SKI complex | • cytoplasm |
| • nucleus | • RNA catabolic process |
Pathways
• RNA exosome pathway
• 3'-5' RNA degradation
Protein Summary
SKIC8 is a 305-amino acid protein containing WD40 repeats, which mediate protein-protein interactions. It is a core component of the SKI complex, along with SKI2 and SKI3, and is required for exosome-mediated RNA degradation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SKIC8 Knockout HEK293 Cell Line | EDJ-KQ15272 | Human | 80349 | Details Get a Quote |
| SKIC8 Knockout A-549 Cell Line | EDJ-KQ45969 | Human | 80349 | Details Get a Quote |
| SKIC8 Knockout HeLa Cell Line | EDJ-KQ45971 | Human | 80349 | Details Get a Quote |
| SKIC8 Knockout HCT 116 Cell Line | EDJ-KQ48158 | Human | 80349 | Details Get a Quote |
