SIGLEC16
Sialic Acid Binding Ig Like Lectin 16
Gene Information Card
| Symbol | SIGLEC16 |
|---|---|
| Full Name | Sialic Acid Binding Ig Like Lectin 16 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.41 |
| NCBI Gene ID | 400709 ncbi.nlm.nih.gov/gene/400709 |
| Ensembl ID | ENSG00000196367 |
| UniProt ID | A6NMY6 |
| OMIM ID | 609403 |
| HGNC ID | 24637 |
| Aliases | SIGLEC-16, SIGLECP16, Siglec-16 |
Description
SIGLEC16 (Sialic Acid Binding Ig Like Lectin 16) is a protein-coding gene located on chromosome 19q13.41. It encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. SIGLEC16 is a transmembrane receptor that recognizes sialic acids on glycoproteins and glycolipids, modulating immune cell signaling. It is expressed predominantly in immune tissues and is involved in cell-cell interactions and immune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Alzheimer disease | Potential role in neuroinflammation via microglial activation | Limited evidence; association studies |
| Cancer (various) | Altered expression may affect tumor immune evasion | Expression profiling studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 2.5 | Low |
| Lung | 1.8 | Low |
| Whole blood | 0.9 | Not detected |
| Brain | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 3.2 | Moderate expression |
| U937 (monocyte) | 2.1 | Low expression |
| HEK293 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs61735836 | missense | 0.1% (global) | Unknown functional effect |
| rs143713587 | missense | 0.05% (global) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No confirmed dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • carbohydrate binding | • protein binding |
| • sialic acid binding | • plasma membrane |
| • integral component of membrane | • cell adhesion |
| • immune response |
Pathways
• Siglec signaling pathway
• Immune system
Protein Summary
SIGLEC16 is a transmembrane protein of the Siglec family, characterized by an N-terminal V-set immunoglobulin-like domain that binds sialic acids. It contains a cytoplasmic tail with immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit phosphatases to modulate signaling. SIGLEC16 is expressed on macrophages and microglia, where it may regulate inflammatory responses. Its exact physiological role remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SIGLEC16 Knockout HEK293 Cell Line | EDJ-KQ11580 | Human | 400709 | Details Get a Quote |
| SIGLEC16 Knockout HCT 116 Cell Line | EDJ-KQ39917 | Human | 400709 | Details Get a Quote |
| SIGLEC16 Knockout HeLa Cell Line | EDJ-KQ38594 | Human | 400709 | Details Get a Quote |
| SIGLEC16 Knockout A-549 Cell Line | EDJ-KQ39916 | Human | 400709 | Details Get a Quote |
