SIGLEC14 Gene - Sialic Acid Binding Ig Like Lectin 14

SIGLEC14 (Sialic Acid Binding Ig Like Lectin 14) is a protein-coding gene located on chromosome 19q13.41. It encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family, which are transmembrane receptors expressed predominantly on immune cells. SIGLEC14 recognizes sialic acid residues on glycoproteins and glycolipids, modulating immune cell signaling and inflammatory responses. The gene is closely related to SIGLEC5 and exhibits allelic variation, including a common fusion with SIGLEC5 in some populations.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Immune System (Reactome: R-HSA-168256)

• Sialic acid metabolism (KEGG: hsa00520)

SIGLEC14 is a transmembrane protein of the Siglec family, characterized by an N-terminal V-set immunoglobulin domain that binds sialic acid, followed by a C2-set domain and a cytoplasmic tail containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). It is expressed on monocytes, macrophages, neutrophils, and a subset of NK cells. Upon ligand engagement, SIGLEC14 recruits phosphatases such as SHP-1 and SHP-2 to dampen activating signals, thereby regulating inflammatory responses. The protein shares high homology with SIGLEC5, and a common deletion polymorphism fuses SIGLEC14 with SIGLEC5, creating a chimeric receptor with altered function.