SGPP2: Sphingosine-1-Phosphate Phosphatase 2
A key regulator of sphingolipid metabolism with roles in immune signaling and cancer
Gene Information Card
| Symbol | SGPP2 |
|---|---|
| Full Name | Sphingosine-1-Phosphate Phosphatase 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q36.1 |
| NCBI Gene ID | 130367 ncbi.nlm.nih.gov/gene/130367 |
| Ensembl ID | ENSG00000163069 |
| UniProt ID | Q8IWX5 |
| OMIM ID | 612123 |
| HGNC ID | 29480 |
| Aliases | SPP2, SPP-2, S1P phosphatase 2 |
Description
SGPP2 encodes sphingosine-1-phosphate phosphatase 2, an enzyme that catalyzes the dephosphorylation of sphingosine-1-phosphate (S1P) to sphingosine. This reaction is critical for regulating intracellular S1P levels, which influence cell proliferation, survival, migration, and immune cell trafficking. SGPP2 is involved in sphingolipid metabolism and has been implicated in inflammatory responses and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Altered S1P signaling due to SGPP2 dysregulation may promote tumor growth and metastasis. | COSMIC; PMID: 25691885 |
| Colorectal cancer | SGPP2 overexpression correlates with poor prognosis; modulates S1P-mediated cell migration. | COSMIC; PMID: 27323851 |
| Inflammatory bowel disease | SGPP2 expression is upregulated in inflamed mucosa, affecting S1P-driven immune cell recruitment. | ClinVar; PMID: 23505227 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Small intestine | 8.3 | Medium |
| Spleen | 6.1 | Low |
| Lung | 4.2 | Low |
| Kidney | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| Caco-2 | 9.7 | Colorectal adenocarcinoma cell line |
| THP-1 | 7.4 | Monocytic leukemia cell line |
| HEK293 | 2.1 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% | Reduced phosphatase activity in vitro (UniProt) |
| c.1246G>A (p.Gly416Arg) | Missense | <0.01% | Unknown functional effect (ClinVar) |
| c.1472_1473insA (p.Asn491Lysfs*5) | Frameshift | <0.01% | Predicted loss of function (COSMIC) |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein or disrupt the catalytic domain are predicted to impair S1P dephosphorylation.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in curated databases.
Dominant Negative (DN)
No evidence for dominant-negative effects in current literature.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Sphingolipid metabolism (Reactome: R-HSA-428157)
• S1P signaling (KEGG: hsa04071)
• Sphingosine-1-phosphate pathway (WikiPathways: WP1423)
Protein Summary
SGPP2 is a 503-amino acid integral membrane protein localized to the endoplasmic reticulum. It belongs to the type 2 phosphatidic acid phosphatase family and contains a conserved phosphatase domain. The enzyme specifically dephosphorylates sphingosine-1-phosphate, thereby controlling the balance between pro-survival S1P and pro-apoptotic ceramide. SGPP2 is expressed in liver, intestine, and immune tissues, and its dysregulation is linked to cancer and inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SGPP2 Knockout HEK293 Cell Line | EDJ-KQ1752 | Human | 130367 | Details Get a Quote |
| SGPP2 Knockout HCT 116 Cell Line | EDJ-KQ21626 | Human | 130367 | Details Get a Quote |
| SGPP2 Knockout HeLa Cell Line | EDJ-KQ58276 | Human | 130367 | Details Get a Quote |
| SGPP2 Knockout A-549 Cell Line | EDJ-KQ66764 | Human | 130367 | Details Get a Quote |
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